Urolithiasis pp 243-243 | Cite as

Study of Circadian Rhythmicity of Urinary Excretion of Glycosaminoglycans in Normal Subjects and Stone Formers

  • H. Sidhu
  • S. Vaidyanathan
  • A. K. Hemal
  • S. K. Thind
  • R. Nath
  • K. Krishan

Abstract

Glycosaminoglycans (GAGs) are potent inhibitors of calcium-oxalate crystallization and/or crystal aggregation. The urinary concentration of GAGs has been shown to vary over a 24-h period (1). The aim of the present study was to investigate circadian rhythmicity in urinary GAGs concentration in healthy adults and to compare it with that of calcium-oxalate nephrolithiasis patients. Three-h urine samples were collected for 24 h beginning at 0000 h (midnight) from 33 healthy male adults and from 27 patients with calcium-oxalate nephrolithiasis. Urinary GAGs were colorimetrically assayed in terms of glucuronic acid content (1). The data were analyzed by single cosinor rhythmometry and population-mean-cosinor rhythmometry (2).

Keywords

Circadian Rhythmicity Healthy Adult Urinary Concentration Renal Calculus Stone Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    A Hesse, H Wuzel, and W Vahlensieck, Urol. Int. 41: 81 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    W Nelson, YL Tong, JK Lee, and F Halberg, Chronobiologia 6: 305 (1979).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • H. Sidhu
    • 1
  • S. Vaidyanathan
    • 2
  • A. K. Hemal
    • 2
  • S. K. Thind
    • 1
  • R. Nath
    • 1
  • K. Krishan
    • 3
  1. 1.Department of BiochemistryPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of UrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of StatisticsPanjab UniversityChandigarhIndia

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