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Urolithiasis pp 233-233 | Cite as

Ability of Some Carboxylic and Phosphorylated Carboxylic Acids to Prevent Hydroxyapatite and Calcium-Oxalate Precipitation

  • J. D. Sallis
  • N. M. Parker
  • M. Brown
  • R. Shankar

Abstract

Phosphocitrate (PC) strongly inhibits calcium salt crystallization. The inhibitory power seems to reside in the special stereochemical configuration of the molecule, in particular, the relationship between the PO4 and COOH moieties (1), With a goal to formulating new anti-calcifying agents, the structure-activity relationship of PC and several related compounds has been examined.

Keywords

Related Compound Calcify Tissue COOH Group Calcium Salt Base Titration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    G Williams and JD Sallis, Structural factors influencing the ability of compounds to inhibit hydroxyapatite formation, Calcified Tissue Int. 34:169 (1982).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. D. Sallis
    • 1
  • N. M. Parker
    • 1
  • M. Brown
    • 1
  • R. Shankar
    • 1
  1. 1.Department of BiochemistryUniversity of TasmaniaHobartAustralia

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