Urolithiasis pp 225-226 | Cite as

Magnesium Inhibits Octacalcium Phosphate and Apatite but Promotes Whitlockite and Brushite Formation

  • P.-T. Cheng


Magnesium has been recommended for prophylactic use in urolithiasis since Mg is known to inhibit in vitro apatite formation and stabilizes amorphous calcium-magnesium-phosphate (ACMP) (1). However, Cheng et al. (2) have shown that ACMP can transform to hydroxyapatite (HAP), or whitlockite (W; TCP), or brushite (B; DCPD) depending on the Mg/Ca ratio of the solution. It has been suggested that thermodynamic calculations would help us better understand the system, and the various effects of Mg on stone formation.


Stability Constant Calcium Phosphate Thermodynamic Calculation Heterogeneous Nucleation Stone Formation 
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  1. 1.
    AL Boskey and AS Posner, Magnesium stabilization of amorphous calcium phosphate: a kinetic study, Mat. Res. Bull. 9: 907 (1974).CrossRefGoogle Scholar
  2. 2.
    P-T Cheng, JJ Grabher, and RZ LeGeros, Effects of magnesium on calcium phosphate formation, Magnesium 7: 123 (1988).PubMedGoogle Scholar
  3. 3.
    LG Sillen and AE Martel, Stability constants of metal-ion complexes, in: “The Chemical Society” London (1971).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P.-T. Cheng
    • 1
  1. 1.Departments of Pathology and Clinical Biochemistry Mount Sinai HospitalUniversity of TorontoTorontoCanada

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