Magnesium Inhibits Octacalcium Phosphate and Apatite but Promotes Whitlockite and Brushite Formation
Magnesium has been recommended for prophylactic use in urolithiasis since Mg is known to inhibit in vitro apatite formation and stabilizes amorphous calcium-magnesium-phosphate (ACMP) (1). However, Cheng et al. (2) have shown that ACMP can transform to hydroxyapatite (HAP), or whitlockite (W; TCP), or brushite (B; DCPD) depending on the Mg/Ca ratio of the solution. It has been suggested that thermodynamic calculations would help us better understand the system, and the various effects of Mg on stone formation.
KeywordsStability Constant Calcium Phosphate Thermodynamic Calculation Heterogeneous Nucleation Stone Formation
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