Suppression of Struvite and Newberyite Bladder-Stone Formation in Rats by Phosphocitrate
Struvite (Mg(NH4)2PO4·6H2O) stones which commonly form with urinarytract bacterial infection comprise approximately 10–15% of all human stones (1). Another recognized Mg2+ crystal-salt form prevalent in many species (but not as common in man), is newberyite (MgHPO4·3H2O). To date, limited research has been undertaken to develop and study compounds capable of restricting the recurrence of Mg2+ salt crystallization. Phosphocitrate (PC) is a compound of interest which is primarily recognized for its inhibitory properties against hydroxyapatite crystallization (2–4). However, its inhibitory power toward the crystallization of Mg2+ salts has never been examined. The present studies report on the influence of PC on the formation and deposition of struvite and newberyite in rats.
KeywordsStone Formation Glycolic Acid Bladder Stone Salt Crystallization Stone Composition
Unable to display preview. Download preview PDF.
- 1.S Silcock, Calcium stones in perspective, Scand. J. Urol. Nephrol. 53: 47(1980).Google Scholar