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Urolithiasis pp 201-204 | Cite as

Suppression of Struvite and Newberyite Bladder-Stone Formation in Rats by Phosphocitrate

  • J. D. Sallis
  • R. Siddiqua
  • R. Shankar

Abstract

Struvite (Mg(NH4)2PO4·6H2O) stones which commonly form with urinarytract bacterial infection comprise approximately 10–15% of all human stones (1). Another recognized Mg2+ crystal-salt form prevalent in many species (but not as common in man), is newberyite (MgHPO4·3H2O). To date, limited research has been undertaken to develop and study compounds capable of restricting the recurrence of Mg2+ salt crystallization. Phosphocitrate (PC) is a compound of interest which is primarily recognized for its inhibitory properties against hydroxyapatite crystallization (2–4). However, its inhibitory power toward the crystallization of Mg2+ salts has never been examined. The present studies report on the influence of PC on the formation and deposition of struvite and newberyite in rats.

Keywords

Stone Formation Glycolic Acid Bladder Stone Salt Crystallization Stone Composition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S Silcock, Calcium stones in perspective, Scand. J. Urol. Nephrol. 53: 47(1980).Google Scholar
  2. 2.
    G Williams and JD Sallis, The synthesis of unlabelled and 32P-labelled phosphocitrate and analytical systems for its identification, Anal. Biochem. 102: 365 (1980).PubMedCrossRefGoogle Scholar
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    WP Tew, C Mahle, J Benavides, JE Howard, and AL Lehninger, Synthesis and characterization of phosphocitric acid, a potent inhibitor of hydroxyapatite crystal growth, Biochemistry 19: 1983 (1980).PubMedCrossRefGoogle Scholar
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    R Shankar, S Crowden, and JD Sallis, Phosphocitrate and its analogue N-sulpho-2-amino tricarballylate inhibit aortic calcification, Atherosclerosis 52: 191 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. D. Sallis
    • 1
  • R. Siddiqua
    • 1
  • R. Shankar
    • 1
  1. 1.Department of BiochemistryUniversity of TasmaniaHobartAustralia

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