Multiple Effects of Amino Acids and Tamm-Horsfall Glycoprotein on the Precipitation of Calcium Oxalate
Glutamic acid (Glu), tryptophan (Trp), ornithine (Orn), and Tamm-Horsfall glycoprotein (THP) are potential inhibitors or promoters of calcium oxalate (CaOx) precipitation. Glutamine has been identified as a crystallization modifier (1, 2), while Orn and Trp have been found in urines of stone-forming patients (3) but their role in CaOx formation has not yet been systematically investigated. The role of THP in urolithiasis has been disputed: does it promote (4, 5) or inhibit (6, 7) CaOx crystal growth and aggregation?
KeywordsCalcium Oxalate Calcium Oxalate Monohydrate Crystallization Modifier Amino Acid Glutamine Inhibit Crystal Growth
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