Intestinal Calcium Transport

  • M. J. Favus


The absorption of dietary calcium is variable and incomplete. The efficiency of absorption is regulated to meet skeletal mineral requirements and is also sensitive to dietary calcium intake and circulating levels of 1, 25-dihydroxyvitamin D3 (1, 25(OH)2D3). The events involved in the translocation of calcium across the epithelium from lumen to blood have been studied using a variety of in vivo and in vitro techniques. The results permit construction of a two-component model for calcium transport composed of a transcellular pathway regulated by 1, 25(OH)2D3 and a paracellular pathway sensitive to transepithelial osmotic and electrochemical gradients. This review will focus on the pathways for calcium transport, the driving forces involved, and regulation by 1, 25(OH)2D3. Events at the cellular level, while poorly understood, will also be discussed.


Dietary Calcium Calcium Transport Dietary Calcium Intake Intestinal Calcium Absorption Paracellular Pathway 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. J. Favus
    • 1
  1. 1.Department of MedicineThe University of ChicagoChicagoUSA

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