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Urolithiasis pp 173-176 | Cite as

Functional Heterogeneity of Tamm-Horsfall Glycoprotein Isolated from Urines of Normal Subjects and Idiopathic Calcium-Oxalate Stone Formers and from Human Calcium-Oxalate Kidney Stones

  • B. Hess
  • Y. Nakagawa
  • B. Kim
  • F. L. Coe

Abstract

Tamm-Horsfall glycoprotein (THP) has been described as a promoter or inhibitor of the aggregation of calcium oxalate monohydrate (COM) crystals (1). We have asked whether urinary THP from normal subjects (n THP) and idiopathic calcium oxalate stone formers (sf THP) and THP from human calcium oxalate stones (stone THP) differ in their ability to inhibit the aggregation of COM crystals in vitro, and - if such differences exist -what could be the mechanism of reduced crystal-aggregation inhibition.

Keywords

Calcium Oxalate Axial Ratio Calcium Oxalate Monohydrate Calcium Oxalate Stone Negative Zeta Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Hess
    • 1
    • 2
  • Y. Nakagawa
    • 1
  • B. Kim
    • 1
  • F. L. Coe
    • 1
  1. 1.Nephrology ProgramUniversity of ChicagoChicagoUSA
  2. 2.Department of MedicineUniversity of ZurichZurichSwitzerland

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