Urolithiasis pp 163-164 | Cite as

Theme Poster Session: Inhibitors II

  • C. Y. C. Pak
  • J. D. Sallis


More than 20 years ago, Boyce (1) and Howard (2) introduced the concepts of matrix theory and inhibitor theory of stone formation, respectively. These theories are still very much in vogue today. The normal urinary environment is typically supersaturated with respect to stoneforming salts. The lack of stone formation in normal subjects must, therefore, reflect the presence of inhibitors or a lack of promoter role of matrix or other substances. Conversely, stone formation in patients with nephrolithiasis might be indicative of a lack of inhibitors or a relative excess of promoters.


Stone Formation Calcium Oxalate Relative Excess Pentosan Polysulfate Oxalate Dihydrate 
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  1. 1.
    WH Boyce and JS King, Jr., Present concepts concerning the origin of matrix and stones, Ann. N. Y. Acad. Sci. 104: 563 (1963).PubMedCrossRefGoogle Scholar
  2. 2.
    JE Howard, WC Thomas, LH Smith, LM Barker, and CL Wadkins, A urinary peptide with extraordinary inhibitory powers against biological “calcification” (deposition) of hydroxyapatite crystals, Trans. Assoc. Am. Physicians 79: 137 (1966).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • C. Y. C. Pak
    • 1
    • 2
  • J. D. Sallis
    • 1
    • 2
  1. 1.Center for Mineral Metabolism and Clinical ResearchUniversity of Texas Southwestern Medical Center at DallasDallasUSA
  2. 2.Department of BiochemistryUniversity of TasmaniaHobartAustralia

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