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Urolithiasis pp 133-135 | Cite as

The Effect of Macromolecules on the Crystallization of Calcium Oxalate in Human Urine

  • R. L. Ryall
  • R. M. Harnett
  • C. M. Hibberd
  • K. A. Edyvane
  • V. R. Marshall

Abstract

Recent studies have indicated that significant amounts of macromolecules, particularly Tamm-Horsfall mucoprotein (THM) may be lost in the centrifugation (1) and filtration (2) steps used to prepare urine for in vitro crystallization experiments. The object of this study was to determine what affect the loss of these molecules may have on the crystallization of calcium oxalate (CaOx) from human urine and whether any effects observed could be compensated for by the addition of physiological concentrations of chondroitin sulphate (CS), human serum albumin (HSA), or THM.

Keywords

Human Serum Albumin Chondroitin Sulphate Calcium Oxalate Scan Electron Microscopy Study Metastable Limit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ABSJ Dawnay, C Thorney, and WR Cattell, An improved radioinuminoassay for urinary Tamm-Horsfall glycoprotein, Biochem. J. 206: 461 (1982).PubMedGoogle Scholar
  2. 2.
    RC Wiggins, A Glatfelter, B Kshirsagar, and J Brukman, Procoagulant activity in normal human urine associated with subcellular particles, Kidney Int. 29: 591 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    RL Ryall, CM Hibberd, and VR Marshall, A method for studying inhibitory activity in whole urine, Urol. Res. 13: 285 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • R. L. Ryall
    • 1
  • R. M. Harnett
    • 1
  • C. M. Hibberd
    • 1
  • K. A. Edyvane
    • 1
  • V. R. Marshall
    • 1
  1. 1.Urology Unit, Department of SurgeryFlinders Medical CenterBedford ParkSouth Australia

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