The Effect of Macromolecules on the Crystallization of Calcium Oxalate in Human Urine
Recent studies have indicated that significant amounts of macromolecules, particularly Tamm-Horsfall mucoprotein (THM) may be lost in the centrifugation (1) and filtration (2) steps used to prepare urine for in vitro crystallization experiments. The object of this study was to determine what affect the loss of these molecules may have on the crystallization of calcium oxalate (CaOx) from human urine and whether any effects observed could be compensated for by the addition of physiological concentrations of chondroitin sulphate (CS), human serum albumin (HSA), or THM.
KeywordsHuman Serum Albumin Chondroitin Sulphate Calcium Oxalate Scan Electron Microscopy Study Metastable Limit
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