Urolithiasis pp 129-131 | Cite as

Ultrafiltration Studies Demonstrate Effects of Urinary Macromolecules on Crystallization of Endogenous Calcium Oxalate in Urine

  • D. K. Y. Shum
  • M. D. Gohel
  • M. K. Li


An earlier study (1) suggested that urinary macromolecules capable of inducing nucleation and inhibiting growth of calcium oxalate (CaOx) crystals occur with a higher incidence in urine samples from stone formers than in those from healthy control subjects. The macromolecules mediating such effects differ between stone formers and normal controls, as is evident from the present study.


Calcium Oxalate Crystal Nucleation Calcium Oxalate Crystal CaOx Crystal Artificial Urine 
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  1. 1.
    DKY Shum, MD Gohel, and MK Li, The influence of urinary acidic macromolecules on the crystallization of calcium oxalate in whole urine, in: “Inhibitors of Crystallization in Renal Lithiasis and Related Clinical Applications”, A Martelli, P Buli, and B Marchesini, eds., Acta Medica, Rome (1988).Google Scholar
  2. 2.
    GA Rose and S Sulaiman, Tamm-Horsfall mucoproteins promote calcium oxalate crystal formation in urine: quantitative studies, J. Urol. 127: 177 (1982).PubMedGoogle Scholar
  3. 3.
    Y Nakagawa, MA Ahmed, SL Hall, S Deganello, and FL Coe, Isolation from human calcium oxalate renal stones of nephrocalcin, a glycoprotein inhibitor of calcium oxalate crystal growth, J. Clin. Invest. 79: 1782 (1987).PubMedCrossRefGoogle Scholar
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    DS Scurr, and WG Robertson, Modifiers of calcium oxalate crystallization found in urine. II. Studies on their mode of action in an artificial urine, J. Urol. 136: 505 (1986).PubMedGoogle Scholar
  5. 5.
    RD Bowyer, JG Brockis, and RK McCulloch, Glycosaminoglycans as inhibitors of calcium oxalate crystal growth and aggregation, Clin. Chim. Acta 95: 23 (1979).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • D. K. Y. Shum
    • 1
  • M. D. Gohel
    • 1
  • M. K. Li
    • 2
  1. 1.Department of Applied Biology and Chemical Technology Hong Kong PolytechnicUniversity of Hong KongHong Kong
  2. 2.Department of SurgeryUniversity of Hong KongHong Kong

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