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Urolithiasis pp 117-119 | Cite as

Renal Proximal Tubular Injury and Crystallization of Calcium Oxalate in Rat Urine

  • S. R. Khan
  • R. L. Hackett

Abstract

Ever since Randall (1) proposed that damage to the renal tubular epithelial cells was a prime essential for the permanent deposition of calcium salts, a connection between urothelial injury and urolithiasis has been suspected. Experimental studies (2) have also shown a link between renal tubular epithelial injury and urinary crystal deposition. The nature of this relationship is still, however, not understood. This project was undertaken to study the relationship between renal tubular injury and deposition of calcium oxalate (CaOx) crystals in a rat model.

Keywords

Brush Border Calcium Oxalate Calcium Salt Renal Tubular Epithelial Cell Gentamicin Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A Randall, The etiology of primary renal calculus, Int. Abstr. Surg. 71: 209 (1940).Google Scholar
  2. 2.
    SR Khan and RL Hackett, Calcium oxalate urolithiasis in the rat, is it a model for human stone disease, Scanning Electron Micros. 11: 759 (1985).Google Scholar
  3. 3.
    PG Werness, CM Brown, LH Smith, and B Finlayson, Equil 2: a BASIC computer program for the calculation of urinary saturation, J. Urol. 134: 1242 (1985).PubMedGoogle Scholar
  4. 4.
    B Finlayson, Physico-chemical aspects of urolithiasis, Kidney Int. 13: 344 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    AL Boskey, Current concepts of the physiology and biochemistry of calcification, Clin. Orthopaedics 157: 225 (1981).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • S. R. Khan
    • 1
  • R. L. Hackett
    • 1
  1. 1.Department of Pathology, College of MedicineUniversity of FloridaGainesvilleUSA

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