Renal Proximal Tubular Injury and Crystallization of Calcium Oxalate in Rat Urine
Ever since Randall (1) proposed that damage to the renal tubular epithelial cells was a prime essential for the permanent deposition of calcium salts, a connection between urothelial injury and urolithiasis has been suspected. Experimental studies (2) have also shown a link between renal tubular epithelial injury and urinary crystal deposition. The nature of this relationship is still, however, not understood. This project was undertaken to study the relationship between renal tubular injury and deposition of calcium oxalate (CaOx) crystals in a rat model.
KeywordsBrush Border Calcium Oxalate Calcium Salt Renal Tubular Epithelial Cell Gentamicin Sulphate
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