Urine from mammalian kidneys inhibits the growth of calcium oxalate monohydrate (COM) crystals (1). Because dialysis reduces inhibition only slightly, the major inhibitors must be molecules too large to dialyze. One of the inhibitor molecules is a glycoprotein we have named nephrocalcin because it is of renal origin and contains the amino acid, gamma-carboxyglutamic acid (Gla), characteristic of the bone protein, osteocalcin (2).
KeywordsRenal Cell Carcinoma Calcium Oxalate Proximal Tubule Cell Calcium Oxalate Monohydrate Calcium Oxalate Monohydrate
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