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Urolithiasis pp 859-859 | Cite as

Allopurinol and Dietary Purine Affect Urinary Uric Acid but not Urinary Oxalate Levels

  • G. S. Morris
  • H. A. Simmonds
  • K. J. Van Acker

Abstract

Previously, we and others showed that the ingestion of a non-specific high-purine diet by healthy subjects increased not only urinary uric acid, but urinary oxalate levels as well. Significant reductions in both parameters was noted during concomitant allopurinol therapy. The present more-detailed study was undertaken to investigate this more fully by the use of a strictly-controlled low-purine/low-oxalate dietary regime, together with a single, specific purine additive - the nucleoside, guanosine (the principal purine in beer in which it can occur in concentrations up to 0,3 M). In addition, several different methods for oxalate determination, including GLC, HPLC, and isotacophoresis were investigated in comparison with the enzymatic method used previously.

Keywords

Uric Acid Enzymatic Method Dietary Regime Urinary Oxalate Logical Explanation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    GS Morris, HA Simmonds, PA Toseland, KJ Van Acker, PM Davies, and JH Stutchbury, Br. J. Urol. 60:292 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. S. Morris
    • 1
  • H. A. Simmonds
    • 1
  • K. J. Van Acker
    • 2
  1. 1.Purine Research LaboratoryUMDS Guy’s HospitalLondonUK
  2. 2.Department of PaediatricsUniversity of AntwerpAntwerpBelgium

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