Vitamin-B6 Status and Oxalate Excretion in Patients with Calcium Lithiasis
Studies carried out in animals and man have shown that a reduced vitamin-B6 intake can lead to an increase in the urinary excretion of oxalate and, consequently, to a greater incidence of calcium oxalate (CaOx) stones. On the basis of these observations, it has become common in clinical practice to administer pharmacological doses of this vitamin to patients affected by idiopathic calcium lithiasis who showed a mild hyperoxaluria or urinary excretion of oxalate near the upper limits of the normal range. Although this treatment has been successful in lowering oxalate excretion in some patients, in others it has been completely ineffective. Since opposing results were obtained regarding the B6-nutritional state of the patients undergoing this treatment (1, 2), the aim of the study was to assess plasma and urinary levels of vitamin B6 as well as primary lithogenic factors both in patients with idiopathic calcium lithiasis (SF) and in normal subjects (NS).
KeywordsUric Acid Urinary Excretion Calcium Oxalate Plasma Vitamin Positive Linear Relationship
- 3.JF Gregory and JR Kirk, Am. J. Nutr. 32:879 (1979).Google Scholar