Influence of Single-Dose Alkali Citrate in Hypocitraturic and Hypercalciuric Healthy Subjects
Alkali citrates have been widely accepted for prevention of calcium-oxalate (CaOx) urolithiasis (1, 2). Patients’ compliance to a large extent depends on the necessary rules of drug intake. The ingestion of Oxalyt-CR (t.i.d.) in combination with fluids is rather troublesome for working and travelling patients. Urinary lithogenic substances normally increase during the night due to antidiuresis. Thus, the intake of Oxalyt-CR in the evening is of special importance. This study evaluates whether a single dose therapy with Oxalyt-CR has a significant influence on urinary citrate and Ca excretion in cases of hypocitraturic and hypercalciuric non-stone formers.