Abstract
A great revolution has taken place in the treatment of urolithiasis in the last few years. Percutaneous lithotripsy, which is minimally invasive, and extracorporeal lithotripsy, which is non-invasive, have made the removal of urinary stones much less morbid than the older, open techniques. Not all stones that need to be removed must be removed surgically. Chemolysis of cystine, struvite, and, particularly, uric acid stones is possible. Dissolving stones by an oral program on an outpatient basis would certainly seem more cost-effective than surgical removal. We undertook a prospective study to examine the effectiveness and safety of dissolving uric acid stones. It has long been known that uric acid stones can be dissolved by oral therapy (1–7). However, these reports tend to be retrospective studies of a few cases, and little can be said about the effectiveness and safety of an oral dissolution program. We present our experience with 21 patients who had relatively lucent, minimally obstructive stones.
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References
M Neto, B Pilloff, and JA Simon, Dissolution of renal uric acid calculus with allopurinol and alkalinization of urine: a case report, J. Urol. 115:740 (1976).
SZ Freed, The alternating use of an alkalinizing salt and acetazolamide in the management of cystine and uric stones, J. Urol. 113:96 (1975).
PH Petritsch, Uric acid calculi: results of conservative treatment, Urology 10:536 (1977).
JT Harbaugh, Dissolution of renal calculus with allopurinol: a case report, J. Urol. 100:412 (1968).
S Alexander and H Brendler, Treatment of uric acid urolithiasis with allopurinol: a xanthine oxidase inhibitor, J. Urol. 97:340 (1967).
AA Billings, GL Kandel, and CM Shapiro, Allopurinol therapy for renal uric acid calculi, JAMA 210:2093 (1969).
R Wasko and BA Frankenfield, Allopurinol dissolution of renal uric acid calculi, JAMA 205:801 (1968).
B Finlayson and A Smith, Stability of first dissociable proton of uric acid, J. Chem. En. D. 19:94 (1974).
HD Mitcheson, RG Zamenhof, MS Bankoff, and EL Prien, Determination of the chemical composition of urinary calculi by computerized tomography, J. Urol. 130:814 (1983).
MI Resnick, ED Kursh, and AM Cohen, Use of computerized tomography in the delineation of uric acid calculi, J. Urol. 131:9 (1984).
JE Lingeman, D Newman, JHO Mertz, PG Mosbaugh, RE Steele, RJ Kahnoski, TA Coury, and JR Woods, Extracorporeal shock wave lithotripsy: the Methodist Hospital of Indiana experience, J. Urol. 135:1134 (1986).
GW Drach, S Dretler, W Fair, B Finlayson, J Gillenwater, D Griffith, J Lingeman, and D Newman, Report of the United States cooperative study of extracorporeal shock wave lithotripsy, J. Urol. 135:1127 (1986).
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© 1989 Springer Science+Business Media New York
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Erickson, S.B., Wilson, D.M., Smith, L.H. (1989). Dissolution of Uric Acid Stones. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_260
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DOI: https://doi.org/10.1007/978-1-4899-0873-5_260
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