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Mineralization Inhibitors and Promoters

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Urolithiasis

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Abstract

Studies of idiopathic Ca urolithiasis suggest that in stone formation, macromolecular components of urine and organic matrix may behave both as promoters and inhibitors of crystallization. In general, when present at low levels in supersaturated solutions of the mineralizing salt, inhibitor molecules may adsorb at active growth sites on the developing crystals, thereby reducing the rate of both growth and dissolution reactions. However, if the density of adsorbed moieties on the crystal surface is sufficiently low, the growth steps may advance over the inhibitor molecules and incorporate them into the crystal lattice. Small ion constituents such as citrate, magnesium, and pyrophosphate are also capable of inhibiting the rate of mineral formation but have not been found to promote nucleation.

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Author information

Authors and Affiliations

  1. Chemistry Department, State University of New York at Buffalo, Buffalo, New York, USA

    G. H. Nancollas, S. A. Smesko, A. A. Campbell, M. Coyle-Rees & A. Ebrahimpour

  2. Veterans Administration Medical Center, Buffalo, New York, USA

    M. Binette & J. P. Binette

Authors
  1. G. H. Nancollas
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  2. S. A. Smesko
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  3. A. A. Campbell
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  4. M. Coyle-Rees
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  5. A. Ebrahimpour
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  6. M. Binette
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  7. J. P. Binette
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Editor information

Editors and Affiliations

  1. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker , Roger A. L. Sutton  & E. C. Bert Cameron ,  & 

  2. Southwestern Medical Center, University of Texas, Dallas, Texas, USA

    Charles Y. C. Pak

  3. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    William G. Robertson

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© 1989 Springer Science+Business Media New York

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Nancollas, G.H. et al. (1989). Mineralization Inhibitors and Promoters. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_26

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  • DOI: https://doi.org/10.1007/978-1-4899-0873-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0875-9

  • Online ISBN: 978-1-4899-0873-5

  • eBook Packages: Springer Book Archive

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