Urolithiasis pp 789-791 | Cite as

Prevention of Recurrent Calcium-Oxalate Calculi Through Use of Hydrochlorothiazide Combined with Amiloride

  • B. Ettinger
  • J. T. Citron


While numerous studies have shown that thiazides are effective in prevention of calcium oxalate nephrolithiasis, a number of unanswered questions remain regarding this therapy: 1) why does it work; 2) who will benefit the most; 3) what is the minimum dose; 4) how can side effects be minimized; and 5) how might various co-therapies augment its effects?


Urinary Calcium Calcium Oxalate Calcium Excretion Magnesium Hydroxide Potassium Citrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    D Leppla, R Browne, K Hill, and CYC Pak, Effect of amiloride with or without hydrochlorothiazide on urinary calcium and saturation of calcium salts, J. Clin. Endocrinol. Metab. 57:920 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    B Ettinger, JT Citron, B Livermore, and LI Dolman, Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not, J. Urol. 139:679 (1988).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Ettinger
    • 1
  • J. T. Citron
    • 1
  1. 1.Kaiser Permanente Medical CentersSan Francisco and Walnut CreekUSA

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