Effect of Extract of Hirudo Medicinalis L. Against Adherences of Calcium Oxalate Crystals to Acid-Injured Bladder Mucosa

  • G.-D. Liu
  • J.-Y. He
  • G.-T. Chang
  • X.-A. Yu


The urothelium of the bladder secretes one or more glycosaminoglycans (GAGs) which prevent the adherence of crystals, bacteria, and carcinogens to the urothelium (1–4). In the present study, we examined the antiadhesion properties of Hirudo Medicinalis L., a traditional Chinese medication.


Calcium Oxalate Sulfated Glycosaminoglycan CaOx Crystal Urate Crystal Normal Urothelium 
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  1. 1.
    WB Gill, KL Ruggiero, and MC Fromes, Elevation metastable limits and absence of container surface nucleation for calcium oxalate crystalization in a urothelial-lined system as compared to glass containers, Invest. Urol. 18: 158 (1980).PubMedGoogle Scholar
  2. 2.
    CL Parsons, Prevention of urinary tract infection by the exogenous glycosaminoglycan sodium pentosalpolysulfate, J. Urol. 127: 167 (1982).PubMedGoogle Scholar
  3. 3.
    CL Parsons, C Stauffer, and JD Schmidt, Bladder surface glycosaminoglycan: an efficient mechanism of environmental adaptation, Science 208: 605 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    CL Parsons, Bladder surface glycosaminoglycans layer: efficient mechanism of environmental adaptation, Urology (Suppl. 2) 27: 9 (1986).CrossRefGoogle Scholar
  5. 5.
    L Grenabo, H Hedelin, and S Pettersson, Adherence of urease-induced crystals to rat bladder epithelium, Urol. Res. 16: 49 (1988).PubMedCrossRefGoogle Scholar
  6. 6.
    CL Parsons, B Danielson, and B Feldstrom, Inhibition of sodium urate crystal adherence to bladder surface by polysaccharide, J. Urol. 134: 614 (1985).PubMedGoogle Scholar
  7. 7.
    WB Gill, KW Jones, and KJ Ruggiero, Protective effect of heparin and other sulfated glycosaminoglycans on crystal adhesion to injured urothelium, J. Urol. 127: 152 (1982).PubMedGoogle Scholar
  8. 8.
    CL Parsons, SC Mutholland. amd J Anwar, Antibacterial activity of bladder surface mucin duplicated by exogenous glycosaminoglycan (heparin), Infect. Immun. 24: 552 (1979).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G.-D. Liu
    • 1
  • J.-Y. He
    • 1
  • G.-T. Chang
    • 1
  • X.-A. Yu
    • 1
  1. 1.Department of Urology and Pharmacy, 2nd Affiliated HospitalLanzhou Medical CollegeLanzhou, GanzuR.P. China

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