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Urolithiasis pp 751-751 | Cite as

The Effect of Modified Diets on Urinary Risk Factors in Kidney Stone Disease

  • W. A. Manette
  • R. W. Norman

Abstract

It has been suggested that dietary therapy can manipulate the following urinary risk factors for calcium-oxalate stone disease: low urinary volume, hypercalciuria, hyperoxaluria, and hyperuricosuria. To address this issue, a two-part study was conducted. Part I investigated the effect of a modified fluid/calcium/oxalate/protein diet (MD) on urinary risk factors, and Part II determined if the addition of fiber (MD+F) would provide further benefit. A daily 10-g supplement of dietary fiber was supplied by two Fibermed biscuits (wheat and corn bran). Twenty-one hypercalciuric patients with calcium-oxalate stone disease were included in the study. Four-day food records (analyzed for 10 nutrients) and corresponding 24-h urine collections (analyzed for volume, calcium, oxalate, and uric acid) were assessed three times for each patient: an initial visit prior to any dietary intervention; following a three-month period on the MD; and following a four-week period on the MD+F. There were statistically significant decreases in the dietary energy, protein, fat, calcium, sodium, and oxalate, and an increase in water content following implementation of the MD. This resulted in a mean increase in 24-h urine volumes of 800 ml/day (p<0.001) and a non-significant decrease in the 24-h urinary calcium and oxalate excretion. The MD+F led to an average increase in dietary fiber from 5.9 g/day to 18.1 g/day (p<0.0001), an increase in dietary iron (p<0.0001), and a further reduction in dietary oxalate, but no other dietary changes occurred. The corresponding urine analysis showed a reduction in calciuria when compared to the initial visit (p<0.001) and to the period of MD alone (p<0.05). The 24-h urinary oxalate decreased from an initial value of 0.48 to 0.35 mmol (p<0.01), and urine volumes remained at the levels reported for the period of MD. Urinary uric-acid levels were unchanged following either diet.

Keywords

Dietary Fiber Initial Visit Dietary Iron Oxalate Excretion Kidney Stone Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • W. A. Manette
    • 1
  • R. W. Norman
    • 1
  1. 1.Halifax Infirmary HospitalHalifaxCanada

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