The Effect of Urinary Macromolecules on the Crystal Growth of Calcium Oxalate in Gel

  • W. Achilles
  • B. Reifenberger
  • C. Schalk


Urinary macromolecules (for example, glycosaminoglycans, Tamm-Horsfall mucoprotein, and nephrocalcin) have long been supposed to affect crystal growth processes relevant in urinary stone formation (1, 2), However, data in the literature on this topic have been contradictory.


Crystal Growth Hyaluronic Acid Human Serum Albumin Heparane Sulfate Chondroitin Sulfate 
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  1. 1.
    WG Robertson, DS Scurr, and VJ Sergeant, Ionic and macromolecular modifiers of crystallization of calcium salts in urine, Fortschr. Urol. Nephrol. 23: 1 (1985).CrossRefGoogle Scholar
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    RL Ryall and VR Marshall, The relationship between urinary inhibitory activity and endogenous concentration of glycosaminoglycans and uric acid, Clin. Chim. Acta 141: 197 (1984).PubMedCrossRefGoogle Scholar
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    W Achilles, Methodische neuerungen des kinetischen gelkristallisationsverfahrens (GKV): automatisierte messung des kalxiumoxalatkristallwachstums durch scanning-microskopphotometrie, Fortschr. Urol. Nephrol. 23: 252 (1985).CrossRefGoogle Scholar
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    W Achilles, Kinetic quantification of crystal growth in gel matrices: an efficient model of urinary stone formation, in: this volume, p. 47.Google Scholar
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    W Achilles, C Schalk, E Krzyzanek, and D Coors, The effect of urinary constituents of low molecular weight on the crystal growth of calcium oxalate in gel, in: this volume, p. 219.Google Scholar
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    SD Roberts and MI Resnick, Glycosaminoglycans content of stone matrix, J. Urol. 135: 1078 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • W. Achilles
    • 1
  • B. Reifenberger
    • 1
  • C. Schalk
    • 1
  1. 1.Urologie/Klin. ForschungUniversitätsklinikum MarburgMarburg/LahnGermany

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