Experimental and Computed Inhibition of Calcium Oxalate Precipitation
In order to better understand the influence of certain substances on the nucleation, growth, and aggregation of crystals in urine, researchers have employed several different experimental approaches. Some have elected to carry out their investigations in a stationary test-tube arrangement (1), others have used flow systems (2), and still others have employed a method involving evaporation to produce crystallization (3). Besides these experimental approaches, investigators have demonstrated the usefulness of modelling the ionic equilibria in urine by computer simulation (4). The present study was undertaken to examine the qualitative and quantitative effect of certain ions on calcium oxalate (CaOx) crystallization in a synthetic urine using a combined experimental and theoretical approach.