Sulfur Amino Acids, Thiol Drugs, and Related Mixed Disulfides from Urine Samples of Cystine Stone Patients
The evaluation of sulfur-containing amino acids in urine is of interest in cystinuric subjects since the abnormally-high excretion of cystine, a disulfur amino acid, is responsible for the disease. Furthermore, sulfur drugs such as d-penicillamine (PEN) and 2-mercapto-propionyl-glycine (MPG) are often used in the treatment of cystinuric patients on the basis of a thiol-exchange reaction. Some of the resulting compounds appear in urine and their identification is necessary for a full comprehension of urine chromatograms. This study was designed to identify and determine such compounds in the urine of normal subjects and cystine stone patients.
KeywordsSulfur Amino Acid Lithium Hydroxide Mixed Disulfide Sulfur Drug Full Comprehension
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