Urolithiasis pp 539-541 | Cite as

Circadian Variation of Plasma Oxalate in Normal Healthy Subjects

  • G. P. Kasidas
  • G. A. Rose


The circadian variation of oxalate in urine has previously been reported (1–3) with urinary oxalate levels rising during waking hours and subsequently returning to basal levels during sleep (1). The advent of a routine and reliable continuous-flow enzymatic method (4) for measuring plasma oxalate prompted us to investigate whether such variations exist in blood.


Circadian Variation Urinary Oxalate Oxalate Excretion Urinary Oxalate Excretion Oxalate Level 
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  1. 1.
    TB Hargreave, A Sali, C Mackay, and M Sullivan, Diurnal variation in urinary oxalate, Br. J. Urol. 49: 597 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    HG Tiselius and LE Almgard, The diurnal excretion of oxalate and the effect of pyridoxine and ascorbate on oxalate excretion, European Urol. 3: 41 (1977).Google Scholar
  3. 3.
    EW Vahlensieck, D Back, and A Hesse, Circadian rhythm of lithogenic substances in urine, Urol. Res. 10: 195 (1982).PubMedGoogle Scholar
  4. 4.
    GP Kasidas and GA Rose, Measurement of plasma oxalate in healthy subjects and in patients with chronic renal failure using immobilized oxalate oxidase, Clin. Chim. Acta 154: 49 (1986).PubMedCrossRefGoogle Scholar
  5. 5.
    GP Kasidas and GA Rose, Continuous flow assay for urinary oxalate using immobilized oxalate oxidase, Ann. Clin. Biochem. 20: 412 (1985).Google Scholar
  6. 6.
    AM Finch, GP Kasidas, and GA Rose, Urine composition in normal subjects after oral ingestion of oxalate rich foods, Clin. Sci. 60: 411 (1981).PubMedGoogle Scholar
  7. 7.
    GP Kasidas and GA Rose, Oxalate content of some common foods: determination by an enzymatic method, J. Human Nutrition 35: 256 (1980).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. P. Kasidas
    • 1
    • 2
  • G. A. Rose
    • 1
    • 2
  1. 1.Biochemistry DepartmentSt. Peter’s HospitalsLondonUK
  2. 2.Institute of UrologyLondonUK

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