Urolithiasis pp 523-525 | Cite as

Contrasting Effects of Various Potassium Salts on Acid-Base Status, Urinary Citrate Excretion, and Renal Citrate Clearance

  • K. Sakhaee
  • C. Y. C. Pak

Abstract

Recently, we have demonstrated that hypocitraturia is a common finding in patients with nephrolithiasis (1). Oral potassium citrate (K-Citrate) treatment has been effective in enhancing renal citrate excretion in such patients (2). The citraturic action of potassium citrate is believed to be the result of the alkali load provided, affecting the renal handling of citrate (2). However, there are data indicating that renal citrate metabolism is affected by bicarbonate ions separate from any action on blood pH (3). Potassium may also play a role in controlling renal citrate excretion since hypokalemia decreases urinary citrate excretion (4). Moreover, despite suggestions to the contrary, orally-administered citrate may theoretically increase urinary citrate by escaping metabolic degradation in vivo and appearing directly in the urine. This study was done in order to determine which of the above factors are responsible for the citraturic action of potassium citrate.

Keywords

Renal Tubular Acidosis Potassium Citrate Urinary Tract Obstruction Potassium Bicarbonate Urinary Citrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    CYC Pak, C Fuller, K Sakhaee, GM Preminger, and F Britton, Long-term treatment of calcium nephrolithiasis with potassium citrate, J. Urol. 134: 11 (1985).PubMedGoogle Scholar
  2. 2.
    K Sakhaee, M Nicar, K Hill, and CYC Pak, Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone forming salts, Kidney Int. 24a: 348 (1983).CrossRefGoogle Scholar
  3. 3.
    DP Simpson, Influence of plasma bicarbonate concentration and pH on citrate excretion, Am. J. Physiol. 206: 875 (1964).PubMedGoogle Scholar
  4. 4.
    S Adler, B Zett, and B Anderson, Renal citrate in the potassium deficient rat: role of potassium and chloride ions, J. Lab. Clin. Med. 84: 307 (1974).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • K. Sakhaee
    • 1
  • C. Y. C. Pak
    • 1
  1. 1.University of Texas Southwestern Medical Center at DallasDallasUSA

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