Urolithiasis pp 497-500 | Cite as

Biochemistry of Citrate

  • D. P. Simpson


The metabolism of citrate has been a prominent topic in biochemistry since the discovery of the tricarboxylic acid cycle by Krebs in the 1930’s. However, as a subject of clinical interest, renal citrate excretion and metabolism have only recently come into vogue. The current interest in this subject arises from recent emphasis on the role of decreased citrate excretion in the pathogenesis of urolithiasis, and from the use of potassium citrate in treating certain types of recurrent stone formation.


Brush Border Brush Border Membrane Tricarboxylic Acid Cycle Metabolic Alkalosis Potassium Citrate 
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    DP Simpson, Citrate excretion: a window on renal metabolism, Am. J. Physiol. 244: F233 (1983).Google Scholar
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    SH Wright and TM Wunz, Succinate and citrate transport in renal basolateral and brush border membranes, Am. J. Physiol. 253: F432 (1987).PubMedGoogle Scholar
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    DP Simpson, Dissociation of acid-base effects on substrate accumulation and on pH in dog mitochrondria, Am. J. Physiol. 254: F863 (1988).PubMedGoogle Scholar
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    WR Adam, AP Koretsky, and MW Weiner, 31p-NMR in vivo measurement of renal intracellular pH: effects of acidosis and K+ depletion in rats, Am. J. Physiol. 251: F904 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • D. P. Simpson
    • 1
  1. 1.Department of Medicine, University HospitalUniversity of Wisconsin School of MedicineMadisonUSA

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