Endogenous Oxalate Production, Clinical Catastrophes, and Oxalate Urolithiasis
Urinary oxalate is derived largely from endogenous metabolic processes. Using isolated rat hepatocytes, human liver homogenates, and purified human enzyme preparations, we have studied the metabolic production of glycolaldehyde, a precursor of glycolate, and of hydroxypyruvate, a precursor of glycolaldehyde. Our studies have led us to propose the existence of relatively minor metabolic pathways that link oxalate production to the metabolism of various carbohydrates and drugs (Fig. 1).