Urolithiasis pp 489-490 | Cite as

Endogenous Oxalate Production, Clinical Catastrophes, and Oxalate Urolithiasis

  • R. A. J. Conyers
  • A. M. Rofe
  • R. Bais

Abstract

Urinary oxalate is derived largely from endogenous metabolic processes. Using isolated rat hepatocytes, human liver homogenates, and purified human enzyme preparations, we have studied the metabolic production of glycolaldehyde, a precursor of glycolate, and of hydroxypyruvate, a precursor of glycolaldehyde. Our studies have led us to propose the existence of relatively minor metabolic pathways that link oxalate production to the metabolism of various carbohydrates and drugs (Fig. 1).

Keywords

Metabolic Acidosis Alcohol Dehydrogenase Aldose Reductase Urinary Oxalate Alfred Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • R. A. J. Conyers
    • 1
  • A. M. Rofe
    • 2
  • R. Bais
    • 2
  1. 1.Department of BiochemistryAlfred HospitalMelbourneAustralia
  2. 2.Division of Clinical ChemistryInstitute of Medical and Veterinary ScienceAdelaideAustralia

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