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Urolithiasis pp 469-470 | Cite as

Oxalate Transport Studies in Intestinal and Renal Brush-Border-Membrane Vesicles in Pyridoxine-Deficient Rats

  • R. Gupta
  • H. Sidhu
  • V. Rattan
  • S. K. Thind
  • R. Nath

Abstract

Nutritional pyridoxine deficiency in rats leads to hyperoxaluria, a major risk factor for calcium-oxalate lithiasis. Oxalate transport across intestinal and renal brush-border-membrane vesicles (BBMV) was studied to understand the mechanism of hyperoxaluria. Acute, subclinical, and chronic pyridoxine deficiencies were induced in male weanling rats. Intestinal and renal BBMV were prepared and tested for purity, vesicularity, and integrity. Oxalate uptake was studied by a rapid filtration technique (1).

Keywords

Major Risk Factor Brush Border Membrane Postgraduate Institute Uptake Intestine Pyridoxine Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    U Hopfer, K Nelson, J Perotto, and KJ Isselbacher, Glucose transport in isolated brush border membrane from rat small intestine, J. Biol. Chenu 248:25 (1973).Google Scholar
  2. 2.
    MSR Murthy, HS Talwar, SK Thind, and R Nath, Vitamin B6 deficiency as related to oxalate synthesizing enzymes in growing rats, Ann. Nutr. Metab. 26:201 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • R. Gupta
    • 1
  • H. Sidhu
    • 1
  • V. Rattan
    • 1
  • S. K. Thind
    • 1
  • R. Nath
    • 1
  1. 1.Department of BiochemistryPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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