Erythrocyte Abnormality in Oxalate Self-Exchange and Urinary Acidification in Idiopathic Calcium-Oxalate Stone Formers
We recently demonstrated an abnormality in oxalate self-exchange in red blood cells (RBC) of idiopathic stone formers (1, 2) which resides in ‘band-three’ protein and is related to its phosphorylation state (3, 4). A protein cross-reacting with antibodies raised against band-3 protein has been demonstrated in renal tubular cells. Therefore, it is likely that the same RBC defect is also present at the renal level. Since the anion-carrier plays a major role in urinary acidification, we have addressed the problem of a possible defect in urinary acidification in renal stone-forming patients with an abnormal RBC oxalate self-exchange.
KeywordsRenal Tubular Cell Urinary Acidification Calcium Oxalate Nephrolithiasis Membrane Protein Phosphorylation Idiopathic Stone
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