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Urolithiasis pp 451-452 | Cite as

Erythrocyte Abnormality in Oxalate Self-Exchange and Urinary Acidification in Idiopathic Calcium-Oxalate Stone Formers

  • G. Gambaro
  • F. Marchini
  • B. Bevilacqua
  • A. Borsatti
  • B. Baggio

Abstract

We recently demonstrated an abnormality in oxalate self-exchange in red blood cells (RBC) of idiopathic stone formers (1, 2) which resides in ‘band-three’ protein and is related to its phosphorylation state (3, 4). A protein cross-reacting with antibodies raised against band-3 protein has been demonstrated in renal tubular cells. Therefore, it is likely that the same RBC defect is also present at the renal level. Since the anion-carrier plays a major role in urinary acidification, we have addressed the problem of a possible defect in urinary acidification in renal stone-forming patients with an abnormal RBC oxalate self-exchange.

Keywords

Renal Tubular Cell Urinary Acidification Calcium Oxalate Nephrolithiasis Membrane Protein Phosphorylation Idiopathic Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    B Baggio, G Gambaro, F Marchini, E Cicerello, and A Borsatti, Raised transmembrane oxalate flux in red blood cells in idiopathic calcium oxalate nephrolithiasis, Lancet 2: 12 (1984).PubMedCrossRefGoogle Scholar
  2. 2.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. Gambaro
    • 1
  • F. Marchini
    • 1
  • B. Bevilacqua
    • 2
  • A. Borsatti
    • 1
  • B. Baggio
    • 1
  1. 1.University of PadovaPadovaItaly
  2. 2.Institute of Internal Medicine and Respiratory Physiopathology LaboratoryUniversity of PadovaPadovaItaly

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