Pharmacokinetic and Autoradiographic Studies on Oxalate in Rats
Animal experiments using radioisotopes have shown that oxalate is mostly generated endogenously (1) and that the renal clearance of oxalate is about 1.3 times that of inulin (2, 3). However, the pharmacokinetics of oxalate are not yet fully known. Therefore, we carried out a pharmacokinetic study of oxalate with reference to inulin (an intracellular marker) in rats. The disappearance of 14C-oxalate from the plasma was analyzed by a two-compartment open model, and the data obtained were compared with those for 3H-inulin. We checked these results in an autoradiographic study on oxalate in rats. Autoradiograms using 14C-oxalate were compared with those using 14C-inulin.
KeywordsPharmacokinetic Study Renal Clearance Calcium Oxalate Total Clearance Urine Flow Rate
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