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Urolithiasis pp 431-433 | Cite as

Pharmacokinetic and Autoradiographic Studies on Oxalate in Rats

  • T. Sugimoto
  • H. Osswald
  • K. Yamamoto
  • T. Kanazawa
  • T. Kishimoto
  • M. Senju
  • M. Maekawa
  • R. Hautmann

Abstract

Animal experiments using radioisotopes have shown that oxalate is mostly generated endogenously (1) and that the renal clearance of oxalate is about 1.3 times that of inulin (2, 3). However, the pharmacokinetics of oxalate are not yet fully known. Therefore, we carried out a pharmacokinetic study of oxalate with reference to inulin (an intracellular marker) in rats. The disappearance of 14C-oxalate from the plasma was analyzed by a two-compartment open model, and the data obtained were compared with those for 3H-inulin. We checked these results in an autoradiographic study on oxalate in rats. Autoradiograms using 14C-oxalate were compared with those using 14C-inulin.

Keywords

Pharmacokinetic Study Renal Clearance Calcium Oxalate Total Clearance Urine Flow Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    C Bannwart, V Hagmaier, G Rutishauser, and H Sieler, Eur. Urol. 5: 276 (1979).PubMedGoogle Scholar
  2. 2.
    TF Knight, HO Senekjian, and EJ Weinman, Kidney Int. 15: 38 (1979).PubMedCrossRefGoogle Scholar
  3. 3.
    R Hautmann and H Osswald, J. Urol. 129: 433 (1983).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • T. Sugimoto
    • 1
  • H. Osswald
    • 2
  • K. Yamamoto
    • 1
  • T. Kanazawa
    • 1
  • T. Kishimoto
    • 1
  • M. Senju
    • 1
  • M. Maekawa
    • 1
  • R. Hautmann
    • 3
  1. 1.Department of UrologyOsaka City University Medical SchoolOsakaJapan
  2. 2.Department of PharmacologyRWTH-AachenUlmGermany
  3. 3.Department of UrologyUlm UniversityUlmGermany

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