Effect of Oxalate on Kidney Mitochondrial Function
We have previously shown that oxalate is transported into mitochondria by the dicarboxylate carrier (1). Since we had postulated that mitochondrial dysfunction contributes to renal stone formation, we predicted that oxalate would affect mitochondrial function in kidney cells to a greater extent than in the liver since calcium-oxalate stones occur only in the kidney. This prediction was examined by comparing the effects of oxalate on two distinct mitochondrial processes - dicarboxylate transport and respiration - in both liver and kidney cortical mitochondria.
KeywordsCalcium Uptake Liver Mitochondrion Mitochondrial Calcium Oxalate Concentration Kidney Mitochondrion
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