The Effect of Vitamin D on Conversion of Ethylene Glycol to Glycolate and Oxalate
Vitamin D3 through its active metabolite, 1, 25(OH)2D3, plays a major role in calcium and phosphorus homeostasis, One-alpha-hydroxy vitamin D (la) is a synthetic analog with very high biological potency which is useful clinically. After administration, the compound is hydroxylated by the liver at the “25 position” on the molecule and converted to 1, 25(OH)2D3. Increased urinary calcium and oxalate excretion are important risk factors for kidney stone formation (1). One-alpha vitamin D3 has been used along with ethylene-glycol (EG) feeding to induce hypercalciuria and hyper-oxaluria, and hence calcium-oxalate kidney stones in experimental rats (2).
KeywordsKidney Stone Glycolic Acid Urinary Oxalate Glyoxylic Acid Oxalate Excretion
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