Glyoxylate is believed to be the immediate precursor of oxalate, and three enzymes, lactate dehydrogenase (LDH), xanthine oxidase (XOD), and glycolate oxidase (GOD) have been known to catalyze the oxidation of glyoxylate to oxalate. In 1979, Fry and Richardson (1) purified an enzyme from human liver which oxidizes glycolate to oxalate without forming glyoxylate as a free intermediate. They named the enzyme “glycolate dehydrogenase (GDH)”. However, which of the four enzymes is mainly responsible for the production of oxalate still remains to be elucidated.
KeywordsXanthine Oxidase Ammonium Sulfate Glycolic Acid Oxalate Oxidase Oxalate Excretion
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