Prostaglandin E2 and Hydrochlorothiazide-Mediated Hypocalciuria: A Hypothesis
Prostaglandin E2 (PGE2) appears to be an important factor in calcium handling by the kidney (1) and has been forwarded as a determinant of hypercalciuria (2, 3). Thiazide diuretics are known to lower Ca excretion, and are widely used to prevent recurrent renal stone formation (4). However, the mechanism(s) by which thiazides lower urinary Ca is unclear. The purpose of this study was to search for a possible link between thiazides and PGE2 in the control of urinary Ca excretion.
KeywordsParathyroid Hormone Thiazide Diuretic Idiopathic Hypercalciuria Rabbit Proximal Tubule PGE2 Excretion
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- 2.AC Buck, JC Cote, and WF Sampson, The influence of prostaglandings on urinary calcium excretion in idiopathic urolithiasis, J. Urol. 122: 421 (1983).Google Scholar
- 3.C Henriquez-La Roche, B Rodriguez-Iturbe, J Herrara, and G Para, Patients with idiopathic hypercalciuria have increased urinary PGE2 excretion, Abstr. Xth Int. Congress of Nephrology, London (1983).Google Scholar
- 6.L Betend, M David, M Vincent, M Hermier, and F Francois, Successful indomethacin treatment of 2 pediatric patients with severe tubulopathies, Helv. Pediatr. Acta 34: 339 (1979).Google Scholar
- 11.RP Robertson and MJ Garrity, Prostaglandin E induces a defect in the regulatory subunit of adenylate cyclase, Clin. Res. 31: 505 (1983).Google Scholar
- 12.JH Dominguez and JB Puschett, Prostaglandin E2 antagonizes the renal effects of parathyroid hormone but not those mediated by a cyclic AMP analog, Mineral Electrolyte Metab. 10: 267 (1984).Google Scholar