Effect of Insulin on Renal Function in Streptozotocin-Treated Rats
The streptozotocin-diabetic rat is accepted to be a good model for studies of renal function in early insulin-dependent diabetes mellitus (Hostetter et al., 1981; Jenson et al., 1981), but the animals are generally studied some weeks after streptozotocin administration. We have investigated renal function in conscious rats 24-h after streptozotocin administration. The primary purpose of this investigation was to clarify the role of insulin in determining urinary calcium excretion.
KeywordsCalcium Excretion Hippuric Acid Urinary Calcium Excretion Renal Prostaglandin Experimental Diabetes Mellitus
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- Anwana, A. and Garland, H.O., 1988, Altered renal calcium handling in experimental diabetes mellitus in the rat-effects of insulin treatment, J. Physiol., 403: 39P.Google Scholar
- Willis, R.G., Green, R., Gordon, C., and Blacklock, N.J., 1984, The influence of glucose and insulin on calcium excretion in the urine, Urol. Res., 12: 209.Google Scholar