Advertisement

Urolithiasis pp 359-361 | Cite as

Effect of Insulin on Renal Function in Streptozotocin-Treated Rats

  • A. C. Buck
  • C. J. Lote
  • S. Head
  • K. Faulkner

Abstract

The streptozotocin-diabetic rat is accepted to be a good model for studies of renal function in early insulin-dependent diabetes mellitus (Hostetter et al., 1981; Jenson et al., 1981), but the animals are generally studied some weeks after streptozotocin administration. We have investigated renal function in conscious rats 24-h after streptozotocin administration. The primary purpose of this investigation was to clarify the role of insulin in determining urinary calcium excretion.

Keywords

Calcium Excretion Hippuric Acid Urinary Calcium Excretion Renal Prostaglandin Experimental Diabetes Mellitus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anwana, A. and Garland, H.O., 1988, Altered renal calcium handling in experimental diabetes mellitus in the rat-effects of insulin treatment, J. Physiol., 403: 39P.Google Scholar
  2. Buck, A.C., Lote, C.J., and Sampson, W.F., 1983, The influence of renal prostaglandings on urinary calcium excretion in idiopathic urolithiasis, J. Urol., 129: 421.PubMedGoogle Scholar
  3. Buck, A.C., Sampson, W.F., Lote, C.J., and Blacklock, N.J., 1982, The influence of renal prostaglandins on glomerular filtration rate and calcium excretion in urolithiaisis, Brit. J. Urol., 53: 485.CrossRefGoogle Scholar
  4. De Fronzo, R.A., Cooke, C.R., Andres, R., Faloona, G.R., and Davis, P.J., 1975, The effect of insulin on renal handling of sodium, potassium, calcium and phosphate in man, J. Clin. Invest., 55: 845.CrossRefGoogle Scholar
  5. De Fronzo, R.A., Goldberg, M., and Agus, Z.S., 1976, The effects of glucose and insulin on renal electrolyte transport, J. Clin. Invest., 58: 83.CrossRefGoogle Scholar
  6. Garland, H.O., and Singh, H.J., 1988, Effects of D-glucose, 2-deoxy D glucose and D xylose on renal function in the rat, J. Physiol., 400: 447.PubMedGoogle Scholar
  7. Hostetter, T.H., Troy, J.L., and Brenner, B.M., 1981, Glomerular haemodynamics in experimental diabetes mellitus, Kidney Int., 19: 410.PubMedCrossRefGoogle Scholar
  8. Jensen, P.K., Christiansen, J.S., Steven, K., and Parving, H.H., 1981, Renal function in streptozotocin-diabetic rats, Diabetologia, 21: 409.PubMedCrossRefGoogle Scholar
  9. Lindeman, R.D., Adler, S., Yiengst, M.J., and Beard, E.S., 1967, Influence of various nutrients on urinary divalent cation excretion, J. Lab. Clin. Med., 70: 236.PubMedGoogle Scholar
  10. Roy, D. R., and Seely, J. F., 1981, Effect of glucose on renal excretion of electrolytes in the rat, Am. J. Physiol., 240: F17.PubMedGoogle Scholar
  11. Willis, R.G., Green, R., Gordon, C., and Blacklock, N.J., 1984, The influence of glucose and insulin on calcium excretion in the urine, Urol. Res., 12: 209.Google Scholar
  12. Wood, R.J., and Allen, L.H., 1983, Evidence for insulin involvement in arginine and glucose-induced hypercalciuria in the rat, J. Nutr., 113: 1561.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • A. C. Buck
    • 2
  • C. J. Lote
    • 1
  • S. Head
    • 1
  • K. Faulkner
    • 1
  1. 1.Department of Physiology, Medical SchoolBirmingham UniversityBirminghamUK
  2. 2.Department of UrologyLeighton HospitalCreweUK

Personalised recommendations