Advertisement

Urolithiasis pp 339-342 | Cite as

Insulin Stimulates Intestinal Calcium Absorption in Man and the Rat

  • G. Rümenapf
  • J. Schmidtler
  • P. O. Schwille

Abstract

Ingestion of carbohydrates leads to abnormally-high plasma-insulin levels in idiopathic hypercalciuric (IHC) Ca-urolithiasis patients (1, 2). In view of the calciuretic effect of insulin (3), hyper-insulinemia has served as one explanation for “idiopathic” hypercalciuria (2). However, the mediators of increased intestinal Ca absorption (CaA) which most of these patients exhibit are largely unknown. Besides enhancing calciuria, insulin affects the metabolism of Ca in many respects. It promotes bone growth in the rat (4), and insulin administration normalizes the low duodenal CaA of streptozotocin-diabetic rats (5). In insulinopenic diabetes, low bone mass is common (6), and so-called diabetic bone disease may ensue. Starting with the hypothesis that postprandial hyper-insulinemia and hyperabsorption of Ca in IHC might be interrelated, we studied the effects of postprandial-like plasma insulin levels on the duodenal CaA of the rat and small intestinal CaA of healthy man.

Keywords

Insulin Infusion Glucose Infusion Intestinal Calcium Absorption Glucose Infusion Rate Duodenal Loop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D Scholz, PO Schwille, and A Sigel, in: “Urolithiasis, Basic and Clinical Research,” LH Smith, WG Robertson, and B Finlayson, eds., Plenum Press, New York (1981). p.795.CrossRefGoogle Scholar
  2. 2.
    PN Rao, C Gordon, D Davies, and NJ Blacklock, Br. J. Urol. 54: 575 (1982).PubMedCrossRefGoogle Scholar
  3. 3.
    RA DeFronzo, CR Cooke, R Andres, GR Faloona, and PJ Davis, J. Clin. Invest. 55: 845 (1975).PubMedCrossRefGoogle Scholar
  4. 4.
    RE Weiss and AH Reddi, Am. J. Physiol. 238: E200 (1980).PubMedGoogle Scholar
  5. 5.
    LE Schneider, JM Nowosielski, and HP Schedi, Endocrinology 100: 67 (1977).PubMedCrossRefGoogle Scholar
  6. 6.
    AL Rosenbloom, DC Lezotte, FT Weber, J Gudat, DR Heller, ML Weber, S Klein, and BB Kennedy, Diabetes 26: 1052 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    G Rümenapf, S Issa, and PO Schwille, Metabolism 36: 60 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    R Wootton and J Reeve, Clin. Sci. 58: 287 (1980).PubMedGoogle Scholar
  9. 9.
    TA Reinhardt, RL Horst, JW Orf, and BW Hollis, J. Clin. Endocrinol. Metab. 58: 91 (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    L Lemann, WF Piering, and EJ Lennon, NEJM 280: 232 (1969).PubMedCrossRefGoogle Scholar
  11. 11.
    G Rümenapf and PO Schwille, in: “Pathogenese und Klinik der Harsteine XI”, G Gasser and W Vahlensieck, eds., Steinkopff, Darmstadt (1985). p. 93.Google Scholar
  12. 12.
    MD Moreno, M Serrano-Rios, and JC Prieto, Front. Hormone Res. 16: 83 (1987).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. Rümenapf
    • 1
  • J. Schmidtler
    • 1
  • P. O. Schwille
    • 1
  1. 1.Mineral Metabolism and Endocrine Research Laboratory Departments of Surgery and UrologyUniversity of ErlangenErlangenGermany

Personalised recommendations