Advertisement

Urolithiasis pp 329-331 | Cite as

Histological and Biochemical Characterization of a Model of Nephrolithiasis Incorporating Proximal Tubular Dysfunction

  • M. Menon
  • T. Strzelecki
  • S. Laxmanan
  • C. Scheid

Abstract

There is now considerable evidence suggesting that tubular dysfunction may contribute to renal stone formation. In certain normocalcernic patients with recurrent calcium-containing kidney stones, this defect is manifest as an impairment of calcium or phosphate reabsorption (1). Other patients exhibit more generalized defects in tubular function, exhibiting impaired reabsorption of water, sodium, bicarbonate, calcium, and magnesium (2, 3). These findings led us to examine an animal model of nephrolithiasis that combines proximal tubular dysfunction with renal stone formation: gentamycin-treated rats fed ammonium oxalate diets. The studies presented here reflect our preliminary assessment of renal structure and function in this animal model.

Keywords

Proximal Tubular Cell Tubular Dysfunction Tubular Function Ammonium Oxalate Idiopathic Hypercalciuria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P Bordier, A Ryckewart, LJ Guerris, and H Rasmussen, On the pathogenesis of so-called idiopathic hypercalciuria, Am. J. Med. 63: 398 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    RAL Sutton and VR Walker, Response to hydrochlorothiazide and acetazolamide in patients with calcium stones. Evidence suggesting a defect in renal tubular function, NEJM 302: 709 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    U Backman, BG Danielson, G Johansson, S Ljunghall, and B Wikström, Incidence and clinical importance of renal tubular defects in recurrent renal stone formers, Nephron 25: 96 (1976).CrossRefGoogle Scholar
  4. 4.
    DC Houghton, M Hartnett, M Campbell-Boswell, G Porter, and W Bennett, A light and electron microscopic analysis of gentamycin nephrotoxicity in rats, Am. J. Pathol. 82: 589 (1976).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Menon
    • 1
  • T. Strzelecki
    • 1
  • S. Laxmanan
    • 1
  • C. Scheid
    • 1
  1. 1.University of Massachusetts Medical SchoolWorcesterUSA

Personalised recommendations