Abstract
Proper classification of patients with undifferentiated hypercalciuria has important diagnostic as well as therapeutic implications. However, when undergoing an outpatient evaluation for recurrent stone disease, some patients with hypercalciuric nephrolithiasis may present with elevation of their fasting urinary calcium with no evidence of parathyroid stimulation. This picture of unclassifed hypercalciuria neither fits the description of absorptive hypercalciuria (normal fasting urinary calcium and normal parathyroid function) or renal hypercalciuria (elevated fasting urinary calcium and parathyroid stimulation). In order to further define this group of patients with unclassified hypercalciuria, we utilized a sodium cellulose phosphate (SCP) trial. This test allowed appropriate identification of patients with true absorptive and renal hypercalciuria and uncovered a small subgroup of patients with persistent hypercalciuria and normal parathyroid function.
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CYC Pak, F Britton, R Peterson, D Ward, C Northcutt, NA Breslau, M McGuire, K Sakhaee, S Bush, M Nicar, D Norman, and PC Peters, Ambulatory evaluation of nephrolithiasis; classificatioh, clinical presentation and diagnostic criteria, Am. J. Med. 69: 19 (1980).
CYC Pak, RA Kaplan, and H Bone, A simple test for the diagnosis of absorptive, resorptive, and renal hypercalciurias, NEJM 292: 497 (1975).
CYC Pak, Medical management of neprolithiasis: Update 1988, J. Urol. In press (1988).
FH Shen, DJ Baylink, RL Nielson, DJ Sharrard, JL Ivey, and MR Haussler, Increased serum 1,25-dihydroxyvitamin D in idiopathic hypercalciuria, J. Lab. Clin. Med. 90: 955 (1977).
AE Broadus, KL Insogna, R Lang, AF Ellison, and BE Dreyer, Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria, NEJM 311: 73 (1984).
AH Tashjian, EF Voelkel, L Levine, and P Goldhaber, Evidence that bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E2, J. Expt. Med. 136: 1329 (1972)/
AC Buck, CJ Lote, and WF Sampson, The influence of renal prostaglandings on urinary calcium excretion in idiopathic urolithiasis, J. Urol. 129: 421 (1983).
GM Preminger and CYC Pak, Eventueal attenuation of hypocalciuric response to HCTZ in absorptive hypercalciuria, J. Urol. 137: 1104 (1987).
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© 1989 Springer Science+Business Media New York
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Preminger, G.M., Peterson, R., Pak, C.Y.C. (1989). Differentiation of Unclassified Hypercalciuria Utilizing a Sodium-Cellulose-Phosphate Trial. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_103
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DOI: https://doi.org/10.1007/978-1-4899-0873-5_103
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