Effects of Combined Application of IL-3 and G-CSF on Subhuman Primates

  • Dorothee Krumwieh
  • Ernst Weinmann
  • Bernhard Siebold
  • Friedrich R. Seiler


In vitro proliferation, differentiation, and functional activation of hematopoietic progenitor cells are regulated by colony-stimulating factors (CSF’s). The four major recombinant human CSF’s—interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and megakaryocyte CSF—have been characterized as mainly responsible for the process whereby bone marrow progenitors mature into granulocytes and macrophages.1 Recent progress in molecular cloning of human and murine genes for these hematopoietic growth and differentiation factors has provided large amounts of highly purified recombinant glycoproteins.2–5 All four factors are also being investigated for their clinical efficacy in alleviating various insufficiencies of the blood-cell-forming system.6–8


Cynomolgus Monkey Hematopoietic Growth Factor Total White Blood Cell Brilliant Cresyl Blue Cresyl Blue 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dorothee Krumwieh
    • 1
  • Ernst Weinmann
    • 1
  • Bernhard Siebold
    • 1
  • Friedrich R. Seiler
    • 1
  1. 1.Research LaboratoriesBehringwerke AGMarburg/LahnFederal Republic of Germany

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