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Rescue of Lethally Irradiated Animals

Therapeutic Use of rhG-CSF and rhGM-CSF in Preclinical Models of Radiation-Induced Marrow Aplasia
  • Thomas J. MacVittie
  • Rodney L. Monroy

Abstract

Three recent radiation accidents—the reactor explosion in Chernobyl, U.S.S.R.,1 the external and internal cesium-137 exposure in Goiânia, Brazil,2 and the cobalt-60 exposure of three technicians in El Salvador, San Salvador—exemplify the usual conditions of accidental radiation exposure. The exposure environment is ill defined and uncontrolled.3 The radiation delivery is heterogeneous and nonuniform, and may vary in rate, quality, and energy. It is the uncontrolled nature of the radiation exposure, in addition to the potential for shielding, that forecasts the possible sparing of cells essential for survival, i.e., the stem cells of the hematopoietic system and the gastrointestinal system. Radiation experiments in which areas of the bone marrow were shielded have demonstrated the potential of spared bone marrow cells to repopulate the hematopoietic tissue and to increase not only the production of granulocytes and platelets but also the chances of surviving an otherwise lethal dose of radiation.4–11

Keywords

Preclinical Model Clinical Support Peripheral White Blood Cell Radiation Accident Survive Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Thomas J. MacVittie
    • 1
  • Rodney L. Monroy
    • 2
  1. 1.Department of Experimental HematologyArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Immunobiology and Transplantation BranchNaval Medical Research InstituteBethesdaUSA

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