Abstract
The exquisite sensitivity of lymphohematopoietic tissues to ionizing radiation has been known since shortly after the discovery of x rays by Roentgen. The most prominent features of the hematopoietic syndrome in experimental animals are hemorrhagic complications and susceptibility to infections. Since the late 1940’s it has been known that the hematopoietic radiation injury could be modified by subsequent infusion of bone marrow. By the mid-1950’s, three independent groups of investigators showed that the lifesaving effect of marrow infusions was due to the presence of pluripotent stem cells in the transplant, from which regrowth of the damaged hematopoietic system occurred.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Thomas, E. D., LeBlond, R., Graham, T., et al. Marrow infusions in dogs given midlethal or lethal irradiation. Radiat Res 41: 113–124, 1970.
Deeg, H. J., Storb, R., Weiden, P. L., et al. High dose total body irradiation and autologous marrow reconstitution in dogs: Dose rate related acute toxicity and fractionation dependent long-term survival. Radiat Res 88: 385–391, 1981.
Deeg, H. J., Storb, R., Longton, G., et al. Single dose or fractionated total body irradiation and autologous marrow transplantation in dogs: Effects of exposure rate, fraction size, and fractionation interval on acute and delayed toxicity. Int J Radiat Oncol Biol Phys 15: 647–653, 1988.
Storb, R., Raff, R. F., Appelbaum, F. R., et al. What radiation dose for DLA-identical canine marrow grafts? Blood 72: 1300–1304, 1988.
Storb, R., Raff, R. F., Appelbaum, F. R., et al. Comparison of fractionated to single dose total body irradiation in conditioning canine littermates for DLA-identical marrow grafts. Blood 74: 1139–1143, 1989.
Deeg, H. J., Storb, R., Shulman, H. M., et al. Engraftment of DLA-nonidentical unrelated canine marrow after high-dose fractionated total body irradiation. Transplantation 33: 443–446, 1982.
Storb, R., and Deeg, H. J. Failure of allogeneic canine marrow grafts after total body irradiation: Allogeneic “resistance” versus transfusion induced sensitization. Transplantation 42: 571–580, 1986.
Schuening, F. G., Storb, R., Goehle, S., et al. Effect of recombinant human granulocyte colony-stimulating factor on hematopoiesis of normal dogs and on hematopoietic recovery after otherwise lethal total body irradiation. Blood 74: 1308–1313, 1989.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Storb, R., Appelbaum, F.R., Schuening, F.G., Raff, R., Graham, T., Deeg, H.J. (1990). Total-Body Irradiation in Bone Marrow Transplantation. In: Browne, D., Weiss, J.F., MacVittie, T.J., Pillai, M.V. (eds) Treatment of Radiation Injuries. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0864-3_4
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0864-3_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0866-7
Online ISBN: 978-1-4899-0864-3
eBook Packages: Springer Book Archive