Abstract
During nuclear disasters, most casualties will receive radiation of various energies, qualities, and doses. In addition, many individuals will die from combined injury, i.e., radiation plus burn and/or wound traumas. Judgments about medical care for casualties with combined injuries, such as those in the Chernobyl accident,1 are difficult to make because clinical experience is limited, and data bases on relevant animal models are lacking. Investigators in our group are studying several complications of tissue trauma on irradiated mice to develop therapies for expected bacterial infections. Specifically, we are examining (1) the impact of radiation quality and type of injury on survival, (2) the effect of timing and extent of injury in combination with irradiation, (3) the hematopoietic responses after combined injury, and (4) the susceptibility of mice with combined injury to opportunistic and Klebsiella pneumoniae infections.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Champlin, R. Treatment of victims of nuclear accidents: The role of bone marrow transplantation. Radiat Res 113: 205–210, 1987.
Ledney, G. D., Stewart, D. A., Gruber, D. F., et al. Hematopoietic colony-forming cells from mice after wound trauma. J Surg Res 38: 55–65, 1985.
Steritz, D. D., Bondi, A., McDermott, D., et al. A burned mouse model to evaluate antipseudomonas activity of topical agents. J Antimicrob Chemother 9: 133–140, 1982.
Stewart, D. A., Ledney, G. D., Baker, W. H., et al. Bone marrow transplantation of mice exposed to a modified fission neutron (N/G 30:1) field. Radiat Res 92: 268–279, 1982.
Ledney, G. D., Exum, E. D., Stewart, D. A., et al. Survival and hematopoietic recovery in mice after wound trauma and whole-body irradiation. Exp Hematol 10 (Suppl 12): 263–278, 1982.
Stromberg, L. W. R., Woodward, K. T., Mahin, D. T., et al. Combined surgical and radiation injury. The effect of timing of wounding and whole body gamma irradiation on 30 day mortality and rate of wound contracture in the rodent. Ann Surg 167: 18–22, 1968.
Madonna, G. S., Ledney, G. D., Elliott, T. B., et al. Trehalose dimycolate enhances resistance to infection in neutropenic animals. Infect Immun 57: 2495–2501, 1989.
McChesney, D. G., Ledney, G. D., and Madonna, G. S. Trehalose dimycolate enhances survival of fission neutron irradiated-mice and Klebsiella pneumoniae-challenged irradiated mice. Radiat Res 121: 71–75, 1990.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ledney, G.D., Madonna, G.S., McChesney, D.G., Elliott, T.B., Brook, I. (1990). Complications of Combined Injury. In: Browne, D., Weiss, J.F., MacVittie, T.J., Pillai, M.V. (eds) Treatment of Radiation Injuries. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0864-3_17
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0864-3_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0866-7
Online ISBN: 978-1-4899-0864-3
eBook Packages: Springer Book Archive