Role of Hematopoietic Growth Factors in Radiation Victims
Total-body exposure to > 1 Gy of ionizing radiation at dose rates > 1 cGy per minute suppresses hematopoiesis in humans. Severity of bone marrow inhibition, duration of decreased blood cell levels, and likelihood of spontaneous recovery are dose dependent in the range of 1–10 Gy. Although experimental and clinical data suggest that some hematopoietic stem cells survive doses of radiation ≥ 10 Gy, hematopoietic recovery is unlikely at higher doses because of toxicity to non hematopoietic organs or because supportive measures are unable to prolong survival long enough for recovery.1–3
KeywordsBone Marrow Failure Nuclear Accident Hematopoietic Growth Factor Capillary Leak Syndrome Hematologic Recovery
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