Role of Hematopoietic Growth Factors in Radiation Victims

RhGM-CSF Following the Goiânia Accident
  • Anna Butturini
  • Robert Peter Gale


Total-body exposure to > 1 Gy of ionizing radiation at dose rates > 1 cGy per minute suppresses hematopoiesis in humans. Severity of bone marrow inhibition, duration of decreased blood cell levels, and likelihood of spontaneous recovery are dose dependent in the range of 1–10 Gy. Although experimental and clinical data suggest that some hematopoietic stem cells survive doses of radiation ≥ 10 Gy, hematopoietic recovery is unlikely at higher doses because of toxicity to non hematopoietic organs or because supportive measures are unable to prolong survival long enough for recovery.1–3


Bone Marrow Failure Nuclear Accident Hematopoietic Growth Factor Capillary Leak Syndrome Hematologic Recovery 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Anna Butturini
    • 1
  • Robert Peter Gale
    • 2
  1. 1.Department of Pediatrics, Division of Hematology and OncologyUniversity of ParmaParmaItaly
  2. 2.Department of Medicine, Division of Hematology-Oncology, School of MedicineUniversity of CaliforniaLos AngelesUSA

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