Trace Element Binding Ligands in Human Milk: Function in Trace Element Utilization

  • Bo Lönnerdal

Abstract

Several essential trace elements are present in human milk in much lower concentrations than in milk from other species or in other infant diets.1 However, recent research has shown that the bioavailability of these trace elements (iron, zinc, copper and manganese) is very high from. human milk.2 As a consequence, trace element deficiency in breast-fed infants is rare.

Keywords

Human Milk Zinc Absorption Infant Formula Plasma Zinc Zinc Bioavailability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B. Lönnerdal, C.L. Keen, and L.S. Hurley, Iron, copper, zinc and manganese in milk, Ann. Rev. Nutr. 1:149 (1981).CrossRefGoogle Scholar
  2. 2.
    B. Lönnerdal, Dietary factors affecting trace element bioavailability from breast-milk, cow’s milk and infant formula, in: “Progress in Food and Nutrition Science,” Vol. 9, R.K. Chandra, ed., Pergamon Press, Inc., Elmsford, NY, pp. 35-62 (1985).Google Scholar
  3. 3.
    G.-B. Fransson and B. Lönnerdal, Iron in human milk, J. Pediatr. 96:380 (1980).CrossRefGoogle Scholar
  4. 4.
    G.-B. Fransson and B. LBnnerdal, Distribution of trace elements and minerals in human and cow’s milk, Pediatr. Res. 17:912 (1983).CrossRefGoogle Scholar
  5. 5.
    B. Lönnerdal, Iron in breast milk, in: “Iron Nutrition in Infancy and Childhood,” A. Stekel, ed., Nestle, Vevey/Raven Press, New York, pp. 95–118 (1984).Google Scholar
  6. 6.
    B.G. Johansson, Isolation of an iron-containing red protein from human milk, Acta Chem. Scand. 14:510 (1960).CrossRefGoogle Scholar
  7. 7.
    P.L. Masson, “La lactoferrine,” Editions Arscia SA, Brussels (1970).Google Scholar
  8. 8.
    M.H. Metz-Boutique, J. Joliés, J. Mazurier, F. Schoentger, D. Legrand, G. Spik, J. Montreuil, and P. Joliés, Human Lactoferrin: amino acid sequence and structural comparisons with other transferrins, Eur. J. Biochem. 145:659 (1984).CrossRefGoogle Scholar
  9. 9.
    G.-B. Fransson and B. Lönnerdal, Iron, copper, zinc, calcium and magnesium in human milk fat, Am. j. Clin. Nutr. 39:185 (1984).Google Scholar
  10. 10.
    J.H. Brock, F. Arzabe, F. Lampreave, and A. Pineiro, The effect of trypsin on bovine transferrin and lactoferrin, Biochim. Biophys. Acta 446:214 (1976).CrossRefGoogle Scholar
  11. 11.
    G. Spik, B. Brunet, C. Mazurier-Dehaine, G. Fontaine, and J. Montreuil, Characterization and properties of the human and bovine lactoferrins extracted from the feces of newborn infants, Acta Paediatr. Scand. 71:974 (1982).CrossRefGoogle Scholar
  12. 12.
    L.A. Davidson and B. LBnnerdal, Lactoferrin and secretory IgA in feces of exclusively breast-fed infants, Am. J. Clin. Nutr. 41:852 (1985).Google Scholar
  13. 13.
    S.M. Donovan, S.A. Atkinson, and B. LBnnerdal, Whey proteins in feces of preterm infants receiving preterm milk and infant formula, in this volume.Google Scholar
  14. 14.
    R.J. Schanler, R.M. Goldblum, C. Garza, and A.S. Goldman, Enhanced fecal excretion of selected immune factors in very low birth weight infants fed fortified human milk, Pediatr. Res. 20:711 (1986).CrossRefGoogle Scholar
  15. 15.
    U.M. Saarinen, M.A. Siimes, and P.R. Dallman, Iron absorption in infants: high bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin, J. Pediatr. 91:36 (1977).CrossRefGoogle Scholar
  16. 16.
    J.A. McMillan, S.A. Landaw, and F.A. Oski, Iron sufficiency in breast-fed infants and the availability of iron from human milk, Pediatrics 58:686 (1976).Google Scholar
  17. 17.
    J.A. McMillan, F.A. Oski, G. Lourie, R.M. Tomarelli, and S.A. Landaw, Iron absorption from human milk, simulated human milk, and proprietary formulas, Pediatrics 55:686 (1975).Google Scholar
  18. 18.
    T.M. Cox, J. Mazurier, G. Spik, J. Montreuil, and T.J. Peters, Iron binding proteins and influx of iron across the duodenal brush border. Evidence for specific lactotransferrin receptors in the human intestine, Biochim. Biophys. Acta 588:120 (1979).CrossRefGoogle Scholar
  19. 19.
    L.A. Davidson and B. LBnnerdal, Isolation and characterization of Rhesus monkey milk lactoferrin, Pediatr. Res. 20:197 (1986).CrossRefGoogle Scholar
  20. 20.
    B. LBnnerdal, L. Davidson, and C.L. Keen, Development of a Rhesus monkey model for the study of iron and manganese from infant diets, Fed. Proc. 44:1850 (1985).Google Scholar
  21. 21.
    L.A. Davidson and B. LBnnerdal, Specific binding of monkey milk lactoferrin to its brush border receptor. Fed. Proc. 44:1673 (1985).Google Scholar
  22. 22.
    L.A. Davidson and B. LBnnerdal, The intestinal lactoferrin receptor: presence and specificity during development, Fed. Proc. 45:588 (1986).Google Scholar
  23. 23.
    J. Mazurier, J. Montreuil, and G. Spik, Visualization of lactotransferrin brush-border receptors by ligand-blotting, Biochim. Biophys. Acta 821:435 (1985).Google Scholar
  24. 24.
    B. LBnnerdal, A.G. Stanislowski, and L.S. Hurley, Isolation of a low molecular weight zinc binding ligand from human milk, J. Inorg. Biochem. 12:71 (1980).CrossRefGoogle Scholar
  25. 25.
    B. LBnnerdal, B. Hoffman, and L.S. Hurley, Zinc and copper binding proteins in human milk, Am. J. Clin. Nutr. 36:1170 (1982).Google Scholar
  26. 26.
    M.T. Martin, K.F. Licklider, J.G. Brushmiller, and F.A. Jacobs, Detection of low molecular weight copper (II) and zinc (II) binding ligands in ultrafiltered milks — the citrate connection, J. Inorg. Biochem. 15:55 (1981).CrossRefGoogle Scholar
  27. 27.
    B. LBnnerdal, C.L. Keen, B. Hoffman, and L.S. Hurley, Copper ligands in human milk: a vehicle for copper supplementation in the treatment of Menkes’ disease?, Am. J. Dis. Child. 134:802 (1980).Google Scholar
  28. 28.
    G.W. Evans and P.E. Johnson, Characterization and quantitation of a zinc-binding ligand in human milk, Pediatr. Res. 14:876 (1980).CrossRefGoogle Scholar
  29. 29.
    L.S. Hurley and B. LBnnerdal, Zinc binding in human milk: citrate versus picolinate, Nutr. Rev. 40:65 (1982).CrossRefGoogle Scholar
  30. 30.
    E.W. Ainscough, A.M. Brodie, and J.E. Plowman, Zinc transport by lactoferrin in human milk, Am. J. Clin. Nutr. 33:1314 (1980).Google Scholar
  31. 31.
    P. Blakeborough, D.N. Salter, and M.I. Gurr, Zinc binding in cow’s milk and human milk, Biochem. J. 209:505 (1983).Google Scholar
  32. 32.
    E.W. Ainscough, A.M. Brodie, and J.E. Plowman, The chromium, manganese, cobalt and copper complexes of human lactoferrin, Inorg. Chim. Acta 33:149 (1979).CrossRefGoogle Scholar
  33. 33.
    B. LBnnerdal, C.L. Keen, and L.S. Hurley, Manganese binding proteins in human and cow’s milk, Am. J. Clin. Nutr. 41:550 (1985).Google Scholar
  34. 34.
    C.D. Eckhert, Isolation of a protein from human milk that enhances zinc absorption in humans, Biochem. Biophys. Res. Comm. 130:264 (1985).CrossRefGoogle Scholar
  35. 35.
    B. Arvidsson, Å. Cederblad, E. Björn-Rasmussen, and B. Sandström, A radionuclide technique for studies of zinc absorption in man, Int. J. Nucl. Med. Biol. 5:104 (1979).CrossRefGoogle Scholar
  36. 36.
    K.M. Hambidge, P.A. Walravens, C.E. Casey, R.M. Brown, and C. Bender, Plasma zinc concentrations of breast-fed infants, J. Pediatr. 94:607 (1979).CrossRefGoogle Scholar
  37. 37.
    C.E. Casey, P.A. Walravens, and K.M. Hambidge, Availability of zinc: loading tests with human milk, cow’s milk, and infant formulas, Pediatrics 68:394 (1981).Google Scholar
  38. 38.
    L.S. Valberg, P.R. Flanagan, J. Brennan, and M.J. Chamberlain, Does the oral zinc tolerance test measure zinc absorption?, Am. J. Clin. Nutr. 41:370(1985).Google Scholar
  39. 39.
    B. SandstrBm, A. Cederblad, and B. LBnnerdal, Zinc absorption from human, cow’s milk and infant formula, Am. J. Dis. Child. 137:726 (1985).Google Scholar
  40. 40.
    B. Sandström, C.L. Keen, B. Lönnerdal, An experimental model for studies of zinc bioavailability from milk and infant formulas using extrinsic labelling, Am. J. Clin. Nutr. 38:420 (1983).Google Scholar
  41. 41.
    B. Lönnerdal, J.G. Bell, A.G. Hendrickx, and C.L. Keen, Improved zinc bioavailability from dephytinized soy formula, Am. J. Clin. Nutr. 43:674 (1986).Google Scholar
  42. 42.
    B. Lönnerdal, C.L. Keen, J.G. Bell, and L.S. Hurley, Zinc uptake and retention from chelates and milk fractions, in “Trace Elements in Man and Animals (TEMA)-5,” C.F. Mills, I. Bremner, and J.K. Chester, eds., Commonwealth Agricultural Bureaux, Farnham Royal, UK, pp. 427-430 (1985).Google Scholar
  43. 43.
    B. Lönnerdal, J.G. Bell, and C.L. Keen, Copper absorption from human milk, cow’s milk and infant formulas using a suckling rat model, Am. J. Clin. Nutr. 42:836 (1985).Google Scholar
  44. 44.
    A. Cordano, Copper deficiency in clinical medicine, in “Zinc and Copper and Clinical Medicine,” K.M. Hambidge and B.L. Nichols, Jr., eds., SP Medical and Scientific Books, New York, pp. 119–126 (1978).Google Scholar
  45. 45.
    C.L. Keen, J.G. Bell, and B. LBnnerdal, The effect of age on manganese status and retention from milk and infant formulas in rats, J. Nutr. 116:395 (1986).Google Scholar
  46. 46.
    J.G. Bell, C.L. Keen, and B. LBnnerdal, Manganese uptake by brush-border membrane vesicles from rat small intestine, Fed. Proc. 45:368 (1986).Google Scholar
  47. 47.
    S.T. Miller, G.C. Cotzias, and H.A. Evert, Control of tissue manganese: initial absence and sudden emergence of excretion in the neonatal mouse, Am. J. Physiol. 229:1980 (1975).Google Scholar
  48. 48.
    B. LBnnerdal, C.L. Keen, M. Ohtake, and T. Tamura, Iron, zinc, copper, and manganese in infant formulas, Am. J. Dis. Child. 137:433 (1983).Google Scholar
  49. 49.
    C.L. Keen, B. LBnnerdal, and L.S. Hurley, Manganese, in “Biochemistry of the Essential Ultratrace Elements,” E. Frieden, ed., Plenum Publ. Co., New York, pp. 89–132 (1985).Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bo Lönnerdal
    • 1
  1. 1.Department of NutritionUniversity of CaliforniaDavisUSA

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