Does Nutrition in Early Life Have Long Term Metabolic Effects? Can Animal Models Be Used to Predict These Effects in the Human?

  • Margit Hamosh
  • Paul Hamosh


The mode of infant feeding is thought to affect the metabolism of the adult. It is the aim of my presentation to evaluate whether infant feeding practice affects lipid metabolism in later life. Specifically, I would like to address the following questions:
  1. 1.

    Does breast feeding alter adipose tissue development in a fashion that protects against obesity in later life?

  2. 2.

    Does early exposure to dietary cholesterol (present in human milk at much higher level than in formula) result in more efficient cholesterol catabolism in the adult and thus in lower incidence of hyper-cholesterolemia and atherosclerosis in later life?

  3. 3.

    Does the unique fatty acid composition of human milk, which provides adequate amounts of docosahexaenoic acid, affect brain composition and function, especially in premature infants?

  4. 4.

    Is membrane structure and function affected by the differences in composition of the fat in human milk and infant formula?



Gastric Emptying Human Milk Breast Feeding Dietary Cholesterol Gastric Inhibitory Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Margit Hamosh
    • 1
  • Paul Hamosh
    • 1
  1. 1.Department of Pediatrics, and Department of Physiology and BiophysicsGeorgetown University Medical CenterUSA

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