Abstract
There is a substantial body of evidence indicating that milk plays an important role in protecting the suckling animal from infections due to viruses and other agents. The presence of antibodies, phagocytes and immunocompetent cells in milk is often cited in support of both nursing and use of banked human milk for nourishment of hospitalized premature newborns. The fact that a variety of animal and human viruses can be transmitted from mother to offspring through milk is not widely recognized. The purpose of this report will be to review the range of viral agents that have been recovered from animal and human milk, to consider the potential importance of milk in transmission of these agents and to assess the implications of this information for nursing mothers and milk banks.
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References
J.F. Ferrer, Bovine leukosis: natural transmission and principles of control, J. Am. Vet. Med. Assoc. 175:1281 (1979).
J.F. Ferrer and C.E. Piper, Role of colostrum and milk in the natural transmission of the bovine leukemia virus, Cancer Res. 41:4906 (1981).
R. Oliver, A. Cathcart, R. McNiven, W. Poole, and G. Robati, Infection of lambs with caprine arthritis encephalitis virus by feeding milk from infected goats, Vet. Rec. 116:83 (1985).
D.W. Hardy, Jr., P.W. Hess, E.G. MacEwen, A.J. McClelland, E.E. Zuckerman, M. Essex, S.M. Cotter, and O. Jarrett, Biology of feline leukemia virus in the natural environment, Cancer Res. 36:582 (1976).
D. Hardy, The virology, immunology and epidemiology of the feline leukemia virus, in: “Feline Leukemia Virus,” W.D. Essex, Jr., A.J. McClelland, eds., Elsevier, New York (1980).
M. Pacitti, O. Jarrett, and D. Hay, Transmission of feline leukaemia virus in the milk of a non-viraemic cat, Vet. Rec. 118:381 (1986).
A.B. Jenson, D.E. Groff, P.J. McConahey, and F.J. Dixon, Transmission of murine leukemia virus (Scripps) from parent to progeny mice as determined by p30 antigenemia, Cancer Res. 36:1228 (1976).
R. Jaenisch, Germ line integration and mendelian transmission of exogenous type C viruses, in: “Molecular Biology of RNA Tumor Viruses,” Academic Press, New York (1980).
M. Zijlstra, R.E.Y. DeGoede, H.J. Schoenmakers, A.H. Schinkel, W.G. Hesselink, J.L. Portis, and C.J.M. Melief, Naturally occurring leukemia viruses in H-2 congenic C57BL mice, III. characterization of C-type viruses isolated from lymphomas induced by milk transmission of B-ecotropic virus, Virology 125:47 (1983).
J.J. Bittner, Some possible effects of nursing on the mammary gland tumor incidence in mice, Science 84:162 (1936).
J. Hilgers and P. Bentvelzen, Interaction between viral and genetic factors in murine mammary cancer, in: “Advances in Cancer Research, Vol. 26,” Academic Press, New York (1978).
P. Hainaut, D. Vaira, C. Francois, C.M. Calberg-Bacq, and P.M. Osterrieth, Natural infection of Swiss mice with mouse mammary tumor virus (MMTV): viral expression in milk and transmission of infection, Arch. Virol. 83:195 (1985).
H.L. Backrach, Foot-and-mouth disease, Ann. Rev. Microbiol. 22:201 (1968).
H. Blackwell, P.D. McKercher, F.V. Kosikowski, L.E. Carmichael, and R.C. Gorewit, Physicochemical transformation of milk components and release of foot-and-mouth disease virus, J. Dairy Res. 50:17 (1983).
P. Sangiorgio and M.C. Weissenbacher, Congenital and perinatal infection with Junin virus in guinea pigs, J. Med. Virol. 11:161 (1983).
J. Nosek, O. Kozuch, E. Ernek, and M. Lichard, The importance of goats in the maintenance of tick-borne encephalitis virus in nature, Acta. Virol. (Praha) 11:470 (1967).
H.W. Reid, D. Buxton, I. Pow, and J. Finlayson, Transmission of louping-ill virus in goat milk, Vet. Rec. 114:163 (1984).
J. Kemeny and R.D. Woods, Quantitative transmissible gastroenteritis virus shedding patterns in lactating sows, Am. J. Vet. Res. 38:307 (1977).
L.J. Saif and E.H. Bohj, Passive immunity to transmissible gastroenteritis virus: intramammary viral inoculation of sows, Ann. NY Acad. Sci. 409:708 (1983).
K. Hayes, D.M. Danks, H. Givas, and I. Jack, Cytomegalovirus in human milk, N. Engl. J. Med. 287:177 (1972).
S. Stagno, D.W. Reynolds, R.F. Pass, and C.A. Alford, Breast milk and the risk of cytomegalovirus infection, N. Engl. J. Med. 302:1073 (1980).
M. Dworsky, M. Yow, S. Stagno, R.F. Pass, and C.A. Alford, Cytomegalovirus infection of breast milk and transmission in infancy, Pediatrics 72:295 (1983).
K. Ahlfors and S.A. Ivarsson, Cytomegalovirus in breast milk of Swedish milk donors, Scand. J. Infect. Dis. 17:11 (1985).
M. Dunkel, R.R. Schmidt, and D.M. O’Connor, Neonatal herpes simplex infection possibly acquired via maternal breast milk, Pediatrics 63:250 (1979).
E. Buimovici-Klein, R.J. Hite, T. Byrne, and L.Z. Cooper, Isolation of rubella virus in milk after postpartum immunization, J. Pediatr. 91:939 (1977).
E.B. Klein, T. Byrne, and L.Z. Cooper, Neonatal rubella in a breast-fed infant after postpartum maternal infection, J. Pediatr. 97:774 (1980).
G.A. Losonsky, J.M. Fishaut, J. Strussenberg, and P.L. Ogra, Effect of immunization against rubella on lactation products. I. development and characterization of specific immunologic reactivity in breast milk, J. Infect. Dis. 145:654 (1982).
G.A. Losonsky, J.M. Fishaut, J. Strussenberg, and P.L. Ogra, Effect of immunization against rubella on lactation products. II. Maternal-neonatal interactions, J. Infect. Dis. 145:661 (1982).
C.C. Linnemann, Jr. and S. Goldberg, HBAg in breast milk, Lancet 2:155 (1974).
E.H. Boxall, T.H. Flewett, P.S. Pane, C.H. Cameron, F.O. MacCallum, and T.W. Lee, Hepatitis-B surface antigen in breast milk, Lancet 2:1007 (1974).
A.K.Y. Lee, H.M.H. Ip, and V.C.W. Wong, Mechanisms of maternal-fetal transmission of hepatitis B virus, J. Infect. Dis. 138:668 (1978).
K. Kinoshita, S. Hino, T. Amagasaki, S. Ikeda, Y. Yamada, J. Suzuyama, S. Momita, K. Toriya, S. Kamihara, and M. Ichimaru, Pemonstration of adult T-cell leukemia virus antigen in milk from three seropositive mothers, Gann. 75:103 (1984).
K. Kinoshita, K. Yamanouchi, S. Ikeda, S. Momita, T. Amagasaki, H. Soda, M. Ichimaru, R. Moriuchi, S. Katamine, T. Miyamoto, and S. Hino, Oral infection of a common marmoset with human T-cell leukemia virus type-I (HTLV-I) by inoculating fresh human milk of HTLV-I carrier mothers, Jpn. J. Cancer Res. 76:1147 (1985).
J.B. Ziegler, R.O. Johnson, P.A. Cooper, and J. Gold, Postnatal transmission of AIPS-associated retrovirus from mother to infant, Lancet 1:896 (1985).
R.F. Pass, Transmission of viruses through human milk, in: “Role of Human Milk in Infant Nutrition and Health,” L.K. Pickering, F.H. Morriss, eds., Charles C. Thomas Publishers, Springfield (1986).
J.Z. Sullivan-Bolyai, K.H. Fife, R.F. Jacobs, Z. Miller, and L. Corey, Pisseminated neonatal herpes simplex virus type 1 from a maternal breast lesion, Pediatrics 71:455 (1983).
R.P. Beasley, C.E. Stevens, I-S Shiao, and H-C Meng, Evidence against breast feeding as a mechanism for vertical transmission of hepatitis B, Lancet 2:740 (1975).
Committee on Fetus and Newborn and Committee on Infectious Piseases, Perinatal herpes simplex virus infections, Pediatrics 66:147 (1980).
A.S. Yeager, F.C. Grumet, E.B. Hafleigh, A.M. Arvin, J.S. Bradley, and C.G. Prober, Prevention of transfusion-acquired cytomegalovirus infection in newborn infants, J. Pediatr. 98:281 (1981).
J.K. Welsch, M. Arsenakis, R.J. Coelen, and J.T. May, Effect of antiviral lipids, heat, and freezing on the activity of viruses in human milk, J. Infect. Dis. 140:322 (1979).
M. Pworsky, S. Stagno, R.F. Pass, G. Cassady, and C.A. Alford, Persistence of cytomegalovirus in human milk after storage, J. Pediatr. 101:440 (1982).
H. Friss and H.K. Andersen, Rate of inactivation of cytomegalovirus in raw banked milk during storage at-20°C and pasteurisation, Br. Med. J. 285:1604 (1982).
R.M. Goldblum, C.W. Pill, T.B. Albrecht, E.S. Alford, C. Garza, and A.S. Goldman, Rapid high-temperature treatment of human milk, J. Pediatr. 104:380 (1984).
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Pass, R.F. (1987). Viral Contamination of Milk. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Å. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_32
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DOI: https://doi.org/10.1007/978-1-4899-0837-7_32
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