The Effect of Feeding Human Milk on the Development of Immunity in Low Birth Weight Infants

  • R. M. Goldblum
  • R. Schanler
  • C. Garza
  • A. S. Goldman


Epidemiologic evidence suggests that infants fed cow’s milk rather than maternal milk have a higher frequency and severity of infectious, allergic, and possibly other inflammatory diseases of the gastrointestinal and respiratory tracts. While some of these illnesses may be attributed to adverse effects of ingesting heterologous milk, some reduction in illness in infants fed maternal milk may reflect alterations in the infants’ immune function. The mechanisms for such protection might include passive transfer of the mucosal immune factors found in high concentration in human milk (1), interactions between the infant’s immune factors and those in the milk (2), or possibly induction by human milk of synthesis or secretion of factors which contribute to the infant’s host defense. However, evidence that any of these mechanisms is operative is limited.


Human Milk Immune Factor Immunologic Factor Maternal Milk Stool Output 
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  1. 1.
    A.S. Goldman, A.J. Ham Pong, R.M. Goldblum. Host Defenses: development and maternal contributions in: “Advances in Pediatrics,” L.A. Barness, ed., Year Book Medical Publishers, Inc. (1985).Google Scholar
  2. 2.
    L. Gothefors, and Marklund, S. Lactoperoxidase activity in human milk and in saliva of newborn infants. Infect. Immun. 11:1210 (1975).Google Scholar
  3. 3.
    R.M. Goldblum, C. Garza, C.A. Johnson, R. Harrist, B.L. Nichols, and A.S. Goldman, Human Milk Banking I. Effects of container upon immunologic factors in mature milk. Nutr. Res. 1:449 (1981).CrossRefGoogle Scholar
  4. 4.
    A.S. Goldman, C. Garza, B.L. Nichols, and R.M. Goldblum, Immunologic factors in human milk during the first year of lactation. J. Pediatr. 100:563 (1982).CrossRefGoogle Scholar
  5. 5.
    A.S. Goldman, R.M. Goldblum, and C. Garza, Immunologie components in human milk during the second year of lactation, Acta. Paediatr. Scand. 72:461 (1983).CrossRefGoogle Scholar
  6. 6.
    A.S. Goldman, R.M. Goldblum, C. Garza, B.L. Nichols, and E.O. Smith, Immunologie components in human milk during weaning, Acta. Paediatr. Scand. 71:133 (1983).CrossRefGoogle Scholar
  7. 7.
    A.S. Goldman, C. Garza, B. Nichols, C.A. Johnson, E.O. Smith, and R.M. Goldblum, Effects of prematurity on the immunologie system in human milk, J. Pediatr. 101:901 (1982).CrossRefGoogle Scholar
  8. 8.
    R.M. Goldblum, C.W. Dill, T.B. Albrecht, E.S. Alford, C. Garza, and A.S. Goldman, Rapid high-temperature treatment of human milk, J. Pediatr. 104:380 (1984).CrossRefGoogle Scholar
  9. 9.
    N.F. Butte, R.M. Goldblum, L.M. Fehl, K. Loftin, E.O. Smith, C. Garza, and A.S. Goldman, Daily ingestion of immunologic components in human milk during the first four months of life, Acta. Paediatr. Scand. 73:296 (1984).CrossRefGoogle Scholar
  10. 10.
    R.J. Schanler, C. Garza, and E.O. Smith, Fortified mothers’ milk for very low birth weight infants: results of macromineral balance studies, J. Pediatr. 107:767 (1985).CrossRefGoogle Scholar
  11. 11.
    R.J. Schanler, R.M. Goldblum, C. Garza, and A.S. Goldman, Enhanced fecal excretion of selected immune factors in very low birth weight infants fed fortified human milk, Ped. Res. 20:711 (1986).CrossRefGoogle Scholar
  12. 12.
    R.M. Goldblum, R.J. Schanler, C. Garza, and A.S. Goldman, Enhanced urinary lactoferrin excretion in premature infants fed human milk, Pediatr. Res. 19:342A (1985).CrossRefGoogle Scholar
  13. 13.
    B. Haneberg, and P. Finne, Lysozymes in feces from infants and children, Acta. Paediatr. Scand. 63:588 (1974).CrossRefGoogle Scholar
  14. 14.
    G. Spik, B. Brunet, C. Mazurier-Dehaine, G. Fontaine, and J. Montreuil. Characterization and properties of the human and bovine lactotransferrins extracted from the feces of newborn infants. Acta Paediatr. Scand. 71:979 (1982).CrossRefGoogle Scholar
  15. 15.
    B. Haneberg, Immunoglobulins in feces from infants fed human or bovine milk, Scand. J. Immunol. 3:191 (1974).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • R. M. Goldblum
    • 1
    • 2
  • R. Schanler
    • 1
    • 2
  • C. Garza
    • 1
    • 2
  • A. S. Goldman
    • 1
    • 2
  1. 1.Departments of Pediatrics and Human Biological Chemistry and GeneticsUniversity of Texas Medical Branch GalvestonUSA
  2. 2.The Section of Neonatology and USDA/ARS Children’s Nutritional Research Center, Department of PediatricsBaylor College of MedicineHoustonUSA

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