Production of Growth Factors by Normal Human Mammary Cells in Culture

  • William R. Kidwell
  • David S. Salomon
  • S. Mohanam
  • Graeme I. Bell


Recent evidence from several laboratories has demonstrated that human breast cancer cell lines produce a variety of polypeptide growth factors, including platelet derived growth factor (PDGF), insulin like growth factor (IGFI), transforming growth factors alpha and beta (TGFα and TGFβ), mammary-derived growth factor I (MDGFI), mammary-derived growth factor II (MDGFII), gastrin releasing peptide (GRP), human mammary tumor growth factor (h.MTGF) and epidermal growth factor (EGF). It has been assumed that production of the factors was a pathological phenomenon, one accompanying neoplastic transformation. However, we and others have shown that most of these are normal components of milk. Consequently, we postulated that the tumor cell-derived factors might be normal glandular secretory products.


Epidermal Growth Factor Human Milk Gastrin Release Peptide Bovine Mammary Gland Polypeptide Growth Factor 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • William R. Kidwell
    • 1
  • David S. Salomon
    • 1
  • S. Mohanam
    • 1
  • Graeme I. Bell
    • 2
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Chiron LabsEmeryvilleUSA

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