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Production of Growth Factors by Normal Human Mammary Cells in Culture

  • William R. Kidwell
  • David S. Salomon
  • S. Mohanam
  • Graeme I. Bell

Abstract

Recent evidence from several laboratories has demonstrated that human breast cancer cell lines produce a variety of polypeptide growth factors, including platelet derived growth factor (PDGF), insulin like growth factor (IGFI), transforming growth factors alpha and beta (TGFα and TGFβ), mammary-derived growth factor I (MDGFI), mammary-derived growth factor II (MDGFII), gastrin releasing peptide (GRP), human mammary tumor growth factor (h.MTGF) and epidermal growth factor (EGF). It has been assumed that production of the factors was a pathological phenomenon, one accompanying neoplastic transformation. However, we and others have shown that most of these are normal components of milk. Consequently, we postulated that the tumor cell-derived factors might be normal glandular secretory products.

Keywords

Epidermal Growth Factor Human Milk Gastrin Release Peptide Bovine Mammary Gland Polypeptide Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • William R. Kidwell
    • 1
  • David S. Salomon
    • 1
  • S. Mohanam
    • 1
  • Graeme I. Bell
    • 2
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Chiron LabsEmeryvilleUSA

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