Abstract
Fatty acid is the main energy substrate in human milk. Since 98% is present as triglyceride, the efficiency of fat utilization is directly dependent on how well the triglyceride is digested and absorbed in the gastrointestinal tract. None the less, our understanding of the principal mechanisms of fat digestion and absorption, and how these are influenced by endogenous and exogenous factors, are still far from complete. There is evidence that this is particularly true for the breastfed infant. In this paper we will focus upon some effects of dietary proteins and phospholipid on digestion of dietary triglyceride.
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B. Fredrikzon, O. Hernell, and L. Bläckberg, Lingual lipase. Its role in lipid digestion in infants with low birthweight and/or pancreatic insufficiency, Acta Pediatr. Scand. 296:75 (1982).
M. Hamosh, Lingual lipase, in: “Lipases”, eds. B. Borgström and H.L. Brockman, Elsevier, Amsterdam (1984).
Y. Gargouri, Les lipases du tractus gastrointestinal, Doctoral thesis, University of Aix-Marseille (1985).
M. Hamosh, and W.A. Burns, Lipolytic activity of human lingual glands (Ebner), Lab. Invest. 37:603 (1977).
J.S. Patton, Gastrointestinal lipid digestion, in: “Physiology of the gastrointestinal tract”, ed. L.R. Johnsson, Raven Press, New York (1981).
B. Fredrikzon, and T. Olivecrona, Decrease of lipase and esterase activities in intestinal contents of newborn infants during test meals, Pediatr. Res. 12:631 (1978).
O. Hernell, L. Bläckberg, B. Fredrikzon, and T. Olivecrona, Bile salt-stimulated lipase in human milk and lipid digestion during the neonatal period, in “Gastroenterology and nutrition in infancy”, ed. E. Lebenthal, Raven Press, New York (1981).
S. Patton, and T.W. Keenan, The milk fat globule membrane, Biochim. Biophys. Acta 415:273 (1975).
J.S. Patton, M.W. Rigler, T.H. Liao, P. Hamosh, and M. Hamosh, Hydrolysis of triacylglycerol emulsions by lingual lipase. A microscopic study, Biochim. Biophys. Acta 712:400 (1982).
L. Bläckberg, O. Hernell, G. Bengtsson, and T. Olivecrona, Colipase enhances hydrolysis of dietary triglycerides in the absence of bile salts, J. Clin. Invest. 64:1303 (1979).
B. Borgström, and C. Erlanson, Interactions of serum albumin and other proteins with porcine pancreatic lipase, Gastroenterology 75:382 (1978).
B. Borgström, The importance of phospholipids, pancreatic phospholipase A2 and fatty acids for the digestion of dietary fat, Gastroenterology 78:954 (1980).
Y. Gargouri, G. Pieroni, C. Riviere, A. Sugihara, L. Sarda, and R. Verger, Inhibition of lipases by proteins: a kinetic study with dicaprin monolayers, J. Biol. Chem. 260:2268 (1985).
Y. Gargouri, G. Pieroni, P.A. Lowe, L. Sarda, and R. Verger, Human gastric lipase. The effect of amphiphiles, Eur. J. Biochem. 156:305 (1986).
L. Bläckberg, O. Hernell, and T. Olivecrona, Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2 and bile salts, J. Clin. Invest. 67:1748 (1981).
Y. Gargouri, K. Khalifa, J. Belleville, and L. Sarda, Effect of long-term feeding soybean flour on pancreatic lipase and colipase levels in rat, J. Nutr. In press.
S. Bernbäck, O. Hernell, and L. Bläckberg, Bovine pregastric lipase: a model for the human enzyme. Properties relevant to its site of action, In preparation.
T. Olivecrona, O. Hernell, T. Egelrud, Å. Billström, H.F. Helander, G. Samuelsson, and B. Fredrikzon, Studies on the gastric lipolysis of milk lipids in suckling rats and human infants, in: “Dietary lipids and postnatal development”, eds. G. Jacini and A. Pecile, Raven Press, New York (1973).
M. Hamosh, Breast milk fat: origin and digestion, in: “Human milk: its social and biological value”, eds. S. Freier and A.I. Edelman, Excerpta Medica ICS No 518 (1980).
O. Hernell, L. Bläckberg, and S. Bernbäck, Milk lipases and in vivo lipolysis, in: “Protein and non-protein nitrogen in human milk”, eds. B. Lönnerdahl and S. Atkinson, CRC Press, New York, In press.
O. Hernell, and L. Bläckberg, Digestion of human milk lipids: physiological significance of sn-2-monoacylglycerol hydrolysis, Pediatr. Res. 16:882 (1982).
S. Bernbäck, O. Hernell, and L. Bläckberg, Purification and molecular characterization of bovine pregastric lipase, Eur. J. Biochem. 148:233 (1985).
R.G.H. Morgan, and B. Borgström, The mechanism of fat absorption in the bile fistula rat, Q.J. Exp. Physiol. 54:228 (1969).
R.O. Scow, P. Desnuelle, and R. Verger, Lipolysis and lipid movement in a membrane model, J. Biol. Chem. 254:6456 (1979).
M.C. Carey, D.M. Small, and C.M. Bliss, Lipid digestion and absorption, Ann. Rev. Physiol. 45:651 (1983).
O. Hernell, L. Bläckberg, and S. Bernbäck, Digestion and absorption of human milk lipids, in: “Perinatal nutrition”, Bristol-Meyers Nutrition Series No 6, Academic Press, New York, In press.
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Hernell, O., Bernbäck, S., Bläckberg, L. (1987). Utilization of Fatty Acids by the Newborn Infant. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Å. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_18
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DOI: https://doi.org/10.1007/978-1-4899-0837-7_18
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