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Hormones and Clinical Anxiety An Imbalanced Neuromodulation of Attention

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Theoretical Foundations of Behavior Therapy

Part of the book series: Perspectives on Individual Differences ((PIDF))

Abstract

In this chapter, a model of neuroses will be developed that suggests that clinical anxiety is an outcome of an interaction between associative conditioning and individual differences in the functioning of the neuroendocrine system. The model takes as an assumption that there is a synergism between these two factors and that each alone is largely insufficient to produce clinical neuroses. More broadly, this interaction can be conveyed by the following equation:

$$ neuroses = conditioning \times neurohormones $$

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References

  • Ahlers, S. T., & Richardson, R. (1985). Administration of dexamethasone prior to training blocks ACTH-induced recovery of an extinguished avoidance response. Behavioral Neuroscience, 99, 760–764.

    Article  PubMed  Google Scholar 

  • Anderson, D. C., Crowell, C., Koehn, D., & Lupo, J. V. (1976). Different intensities of unsignaled inescapable shock treatments as determinants of non-shock-motivated open field behavior: A resolution of disparate results. Physiology and Behavior, 17, 391–394.

    Article  PubMed  Google Scholar 

  • Anderson, L. T., David, R., Bonnet, K., & Dancis, J. (1979). Passive avoidance learning in Lesch-Nyhan disease: Effect of l-desaminio-8-arginine-vasopressin. Life Sciences, 24, 905–910.

    Article  PubMed  Google Scholar 

  • Armario, A., Castellanos, J. M., & Balasch, J. (1984). Effect of crowding on emotional reactivity in male rats. Neuroendocrinology, 39, 330–333.

    Article  PubMed  Google Scholar 

  • Arnsten, A. F. T., Neville, H. J., Hillyard, S. A., Janowsky, D. S., & Segal, D. S. (1984). Naloxone increases electrophysiological measures of selective information processing in humans. Journal of Neuroscience, 4, 2912–2919.

    PubMed  Google Scholar 

  • Aston-Jones, G. (1885). The locus coeruleus: Behavioral functions of locus coeruleus derived from celluar attributes. Physiological Psychology, 13, 118–126.

    Google Scholar 

  • Ballenger, J. C., Post, R. M., Jimerson, D. C., Lake, C. R., & Zuckerman, M. (1984). Neurobiological correlates of depression and anxiety in normal individuals. In R. M. Post & J. C. Ballenger (Eds.), Neurobiology of mood disorders (pp. 481–501). Baltimore, MD: Williams & Wilkins.

    Google Scholar 

  • Bechara, A., & van der Kooy, D. (1985). Opposite motivational effects of endogenous opioids in brain and periphery. Nature, 314, 533–534.

    Article  PubMed  Google Scholar 

  • Beckwith, B. E., & Sandman, C. A. (1978). Behavioral influences of neuropeptides ACTH and MSH: A methodological review. Neuroscience and Behavioral Reviews, 2, 311–338.

    Article  Google Scholar 

  • Beckwith, B. E., & Sandman, C. A. (1982). Central nervous system and peripheral effects of ACTH, MSH, and related peptides. Peptides, 3, 411–420.

    Article  PubMed  Google Scholar 

  • Berettini, W. H., Nurnberger, J. I., Jr., Chan, J. S. D., Chrousos, G. P., Gaspar, L., Gold, P. W., Seidah, N. G., Simmons-Ailing, S., Goldin, L. R., Chretien, M., & Gershon, E. S. (1985). Pro-opiomelan-ocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder. Psychiatry Research, 16, 287–302.

    Article  Google Scholar 

  • Bertolini, A., & Gessa, G. L. (1981). Behavioral effects of ACTH and MSH peptides. Journal of Endocrinological Investigation, 4, 241–251.

    PubMed  Google Scholar 

  • Bertoloni, A., Fratta, W., Gessa, G. L., Montaldo, S., & Serra, G. (1984). Penile erection during morphine withdrawal: Possible role of ACTH-MSH peptides. In E. E. Muller & A. R. Genazzi (Eds.), Central and peripheral endorphins: Basic and clinical aspects. New York: Raven Press.

    Google Scholar 

  • Bertolini, A., Vergoni, A. V., Poggioli, R., & Gessa, G. L. (1986). Morphine and B-endorphin antagonize posture and locomotor disorders induced by the injection of ACTH 1–24 in the rat locus coeruleus. Life Sciences, 38, 373–377.

    Article  PubMed  Google Scholar 

  • Bohus, B., de Kloet, E. R., & Veldius, H. D. (1982). Adrenal steroids and behavioral adaptation: Relationship to brain corticoid receptors. In D. Pfaff & D. Ganten (Eds.), Current topics in neuroendocrinology, Vol. 2 (pp. 107–151). Berlin: Springer-Verlag.

    Google Scholar 

  • Bolles, R. C. (1970). Species-specific defensive reactions and avoidance learning. Psychological Review, 77, 32–48.

    Article  Google Scholar 

  • Born, J., Fehm-Wolfsdorf, G., Schiebe, M., Rockstroh, B., Fehm, H. L., & Voigt, K. H. (1984) Dishabituating effects of an ACTH 4–9 analog in a vigilance task. Pharmacology Biochemistry and Behavior, 21, 513–519.

    Article  Google Scholar 

  • Breggin, P. R. (1964). The psychophysiology of anxiety. The Journal of Nervous and Mental Disease, 139, 558–568.

    Article  PubMed  Google Scholar 

  • Britton, D. R., Varela, M., Garcia, A., & Rosenthal, M. (1986). Dexamethasone suppresses pituitary-adrenal but not behavioral effects of centrally administered CRF. Life Sciences, 38, 211–216.

    Article  PubMed  Google Scholar 

  • Buckingham, J. C., & Cooper, T. A. (1984). Differences in hypothalamo-pituitary-adrenocortical activity in the rat after acute and prolonged treatment with morphine. Neuroendocrinology, 38, 411–417.

    Article  PubMed  Google Scholar 

  • Buijs, R. M. (1983). Vasopressin and oxytocin—Their role in neurotransmission. Pharmacology and Therapeutics, 22, 127–141.

    Article  PubMed  Google Scholar 

  • Burbach, J. P. H., Bohus, B., Kovacs, G. L., van Nispen, J. W. Greven, H. M., & de Wied, D. (1983). Oxytocin is a precursor of behaviorally active neuropeptides. European Journal of Pharmacology, 94, 125–131.

    Article  PubMed  Google Scholar 

  • Burbach, J. P. H., Kovacs, G. L., & de Wied, D. (1983). A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. Science, 221, 1310–1312.

    Article  PubMed  Google Scholar 

  • Cannon, W. B. (1915). Bodily changes in pain, hunger, fear and rage (2nd ed.). New York: Appleton.

    Google Scholar 

  • Carpenter, W. T., & Gruen, P. H. (1982). Cortisol’s effect on human mental functioning. Journal of Clinical Psychopharmacology, 2, 91–101.

    Article  PubMed  Google Scholar 

  • Charney, D. S., & Redmond, D. E., Jr., (1983). Neurobiological mechanisms in human anxiety. Neuropharmacology, 22, 1531–1536.

    Article  PubMed  Google Scholar 

  • Cohen, M. R., Pickar, D., Extein, I., Gold, M. S., & Sweeney, D. R. (1984). Plasma Cortisol and B- endorphin immunoreactivity in major and nonmajor depression. American Journal of Psychiatry, 141, 628–632.

    PubMed  Google Scholar 

  • Cohen, M. R., Cohen, R. M., Pickar, D., Sunderland, T., Mueller, E. A., III, & Murphy, D. L. (1984). High-dose Naloxone in depression. Biological Psychiatry, 19, 825–832.

    PubMed  Google Scholar 

  • Concannon, J. T., Riccio, D. C., Maloney, R., & McKelvey, J., (1980). ACTH mediation of learned fear: Blockade by naloxone and naltrexone. Physiology and Behavior, 25, 977–979.

    Article  PubMed  Google Scholar 

  • Concannon, J. T., Riccio, D. C., & McKelvey, J. (1980). Pavlovian conditioning of fear based upon hormonal mediation of prior aversive experience. Animal Learning and Behavior, 8, 75–80.

    Article  Google Scholar 

  • Cook, L., Davidson, A., Davis, D. J., & Kelleher, R. T. (1960). Epinephrine, norepinephine, and acetylcholine as stimuli for avoidance behavior. Science, 131, 990–991.

    Article  PubMed  Google Scholar 

  • Cronin, G. M., Wiepkema, P. R., & van Ree, J. M. (1986). Endorphins implicated in stereotypies of tethered sows. Experienlia, 42, 198–199.

    Article  Google Scholar 

  • Datta, P. C., & King, M. G. (1982). Alpha-melanocyte-stimulating hormone and behavior. Neuroscience and Biobehavioral Review, 6, 297–310.

    Article  Google Scholar 

  • De Vito, W. J., & Brush, F. R. (1984). Effect of ACTH and vasopressin on extinction: Evidence for opiate mediation. Behavioral Neuroscience, 98, 59–71.

    Article  Google Scholar 

  • de Wied, D. (1984). CNS effects of oxytocin and related peptides. In P. Paccheri, L. Zichella and P. Falaschi (Eds.), Endorphins, neuroregulalors and behavior in human reproduction (pp. 4–15). Princeton: NJ: Excepta Medica.

    Google Scholar 

  • de Wied, D., & Jolies, J. (1982). Neuropeptides derived from pro-opiocortin: Behavioral, psychological and neuro-chemical effects. Physiological Reviews, 62, 976–1067.

    PubMed  Google Scholar 

  • Dolan, R. J., Calloway, S. P., Fonagy, P., De Souza, F. V. A., & Wakling, A. (1985). Life events, depression and the hypothalamic-pituitary-adrenal axis. British Journal of Psychiatry, 147, 429–433.

    Article  PubMed  Google Scholar 

  • Ehrensing, R. H., Micheli, G. F., & Baker, R. P. (1982). Vasopressin’s effects on acquisition and extinction of conditioned avoidance response to smoking. Peptides, 3, 527–530.

    Article  PubMed  Google Scholar 

  • Eich, J. E. (1980). The cue-dependent nature of state-dependent retrieval. Memory and Cognition, 8, 157–173.

    Article  Google Scholar 

  • Ettenburg, A., van der Kooy, D., Le Moal, M., Koob, J., & Bloom, F. (1983). Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory? Behavioural Brain Research, 7, 331–350.

    Article  Google Scholar 

  • Eysenck, H. J. (1979). The conditioning model of neuroses. Behavior and Brain Sciences, 2, 155–199.

    Article  Google Scholar 

  • Eysenck, H. J., & Eysenck, M. W. (1985). Personality and individual differences. New York: Plenum Press.

    Book  Google Scholar 

  • Eysenck, H. J., & Kelley, M.J. (1986). The interaction of neurohormones with Pavlovian A and Pavlovian B conditioning in the causation of neuroses, extinction and incubation of anxiety. In G. Davies (Ed.), Human conditioning. London: Wiley.

    Google Scholar 

  • Fanslow, M. S. (1985). Odors released by stressed rats produce opioid analgesia in unstressed rats.Behavioral Neuroscience, 99, 589–592.

    Article  Google Scholar 

  • Foa, E. B., Stekette, G. S., & Ozarow, B.J. (1985). Behavior therapy with obsessive-compulsives: From theory to treatment. In M. Mavissakalian, S. M. Turner, & L. Michaelson (Eds.), Obsessive-compulsive disorder. New York: Plenum Press.

    Google Scholar 

  • Fehm, H. L., Klien, E., Holl, R., & Voigt, K. H. (1984). Evidence for extra-pituitary mechanisms mediating the morning peak of plasma Cortisol in man. Journal of Clinical Endocrinology and Metabolism, 58, 410–414.

    Article  PubMed  Google Scholar 

  • Fehm, H. L., Holl, R., Steiner, K., Klein, E., & Voigt, K. H. (1984). Evidence for ACTH-unrelated mechanisms in the regulation of Cortisol secretion in man. Klinische Wochenschrift, 62, 19–24.

    Article  PubMed  Google Scholar 

  • Frederiksen, S. O., d’Elia, G., & Bengtsson, B.-O. (1985). ACTH 4–9 analogue (ORG 2766) in depressed and elderly patients. Acta Psychiatrica Scandanavica, 72, 349–357.

    Article  Google Scholar 

  • Fredrikson, M., Sundin, O., & Frankenhaeuser, M. (1985). Cortisol excretion during defensive reaction in humans. Psychosomatic Medicine, 47, 313–317.

    PubMed  Google Scholar 

  • Gaillard, A. W. K. (1981). ACTH analogs and human performance. In J. L. Martinez Jr., R. A. Jensen, R. B. Messing, H. Righter, & J. L. McGuagh (Eds.), Endogenous peptides and learning and memory processes (pp. 181–196). New York: Academic Press.

    Google Scholar 

  • Gjerris, A., Hammer, M., Vendsborg, P., Christensen, N.J., & Rafaelsen, O.J. (1985). Cerebrospinal fluid vasopressin—Changes in depression. British Journal of Psychiatry, 147, 696–701.

    Article  PubMed  Google Scholar 

  • Gold, P. W., Ballenger, J. C., Robertson, G. L., Weingartner, H., Rubinow, D. R., Hoban, M. C., Goodwin, F. K., & Post, R. N. (1984). Vasopressin in affective illness: direct measurement, clinical trials and response to hypertonic saline. In R. M. Post & J. C. Ballenger (Eds.), Neurobiology of mood disorders (pp. 323–339). London: Williams & Wilkins.

    Google Scholar 

  • Gold, P. W., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. L. (1984). Psychiatric and clinical studies of corticotropin releasing factor. The American Journal of Psychiatry, 141, 619–627.

    PubMed  Google Scholar 

  • Gold, P. W., Kaye, W., Robertson, G. L., & Ebert, M. (1984). Abnormal regulation of argine vasopressin plasma and cerebrospinal fluid of patients with anorexia nervosa. New England Journal of Medicine, 308, 1117–1123.

    Article  Google Scholar 

  • Gray, P. (1975). Effect of adrenocorticotropic hormone on conditioned avoidance in rats interpreted as state-dependent learning. Journal of Comparative and physiological Psychology, 88, 281–284.

    Article  PubMed  Google Scholar 

  • Greenberg, D., & Belmaker, R. H. (1985). DDAVP as a possible method to enhance positive benefit of behaviour therapy. British Journal of Psychiatry, 147, 713–715.

    Article  PubMed  Google Scholar 

  • Grossen, N. E., & Kelley, M.J. (1972). Species-specific behavior and acquisition of avoidance behavior in rats. Journal of Comparative and Physiological Psychology, 81, 306–311.

    Article  Google Scholar 

  • Hagen, J. J., & Bohus, B. (1984). Vasopressin prolongs bradycardiac response during orientation. Behavioral and Neural Biology, 41, 77–83.

    Article  Google Scholar 

  • Haroutunian, V., & Riccio, D. C. (1977). The effect of arousal conditions during reinstatement treatment upon learned fear in young rats. Developmental Psychobiology, 10, 25–32.

    Article  PubMed  Google Scholar 

  • Haroutunian, V., & Riccio, D. C. (1979). Drug-induced “arousal” and the effectiveness of CS exposure in the reinstatement of memory. Behavioral and Neural Biology, 26, 115–120.

    Article  PubMed  Google Scholar 

  • Hayashi, T., Fischman, A. J., Kaskin, A. A., & Coy, D. H. (1984). Some analogs of Try-MIF-1 affect passive avoidance behavior but not motor activity in rats. Pharmacology Biochemistry and Behavior, 21, 809–812.

    Article  Google Scholar 

  • Henry, J. L. (1982). Circulating opioids: possible physiological roles in central nervous system. Neuroscience and Biohehavioral Reviews, 6, 229–245.

    Article  Google Scholar 

  • Hernandez, L. L. (1985). Vasopressin and ACTH analogs affect orienting but not activity in rabbits. Peptides, 2, 97–101.

    Article  Google Scholar 

  • Heuman, K. F. (Ed.). (1985). Proceedings of conference on corticotropin-releasing factor. Federal Proceedings, 44, 145–263.

    Google Scholar 

  • Iversen, L. L. (1984). Amino acids and peptides: fast and slow chemicals in the nervous system? Proceedings of the Royal Society of London, 221, 245–260.

    Article  PubMed  Google Scholar 

  • Izquierdo, I., Perry, M. L., Dias, R. D., Souza, D. O., Elisabetsky, E., Carrasco, M. A., Orsingher, O. A., & Netto, C. A. (1981). Endogenous opioids, memory modulation, and state dependency. In J. L. Martinez Jr., R. A. Jensen, R. B. Messing, H. Rigter, & J. L. McGaugh (Eds.), Endogenous peptides and learning and memory processes (pp. 269–304). New York: Academic Press.

    Google Scholar 

  • Jacquet, Y. (1978). Opiate effects after adrenocorticotropin or B-endorphin injection in the periaqueductal grey matter of rats. Science, 201, 1032–1034.

    Article  PubMed  Google Scholar 

  • Jarbe, T. U. C., Svensson, R., & Laaksonen, T., (1983). Conditioning of a discriminative drug stimulus: overshadowing and blocking procedures. Scandinavian Journal of Psychology, 24, 325–330.

    Article  PubMed  Google Scholar 

  • Jenkins, J. S., Ang, V. T. Y., Hawthorn, J., Rossor, M. N., & Iversen, L. (1984). Vasopressin, oxytocin and neurophysins in the human brain and spinal cord. Brain Research, 291, 111–117.

    Article  PubMed  Google Scholar 

  • Jennings, J. R., Nebes, R. D., & Reynolds, C. F., III. (1986). Vasopressin peptide (DDAVP) may narrow the focus of attention in normal elderly. Psychiatry Research, 17, 31–39.

    Article  PubMed  Google Scholar 

  • Kalin, N. E. (1986). ACTH in plasma and CSF in the Rhesus monkey. Biological Psychiatry, 21, 124–140.

    Article  PubMed  Google Scholar 

  • Kastin, A. J., Olson, R. D., Sandman, C. A., & Coy, D. H. (1981). Multiple independent actions of neuropeptides on behavior. In J. L. Martinez Jr., R. A. Jensen, R. B. Messing, H. Rigter, & J. L. McGaugh (Eds.), Endogenous Peptides and Learning and Memory Processes (pp. 563–578). New York: Academic Press.

    Google Scholar 

  • Kasprow, W. J., Catterson, D., Schachtman, T. R., & Miller, R. R. (1984). Attenuation of latent inhibition by post-acquisition reminder. Quarterly Journal of Experimental Psychology, 36B, 53–63.

    Google Scholar 

  • Kelley, M.J. (1982). Event-reinforcer interactions in conditioning. Unpublished D. Phil, thesis at The University of Sussex.

    Google Scholar 

  • Kelley, M.J. (1985a). Epinephrine-cue contiguity is required for the modulation of CS excitatory strength. Physiological Psychology, 13, 217–218.

    Google Scholar 

  • Kelley, M J. (1985b). Species-typical taxic behavior and event-reinforcer reactions. Learning and Motivation, 16, 301–314.

    Article  Google Scholar 

  • Kelley, M.J. (1986a). Selective attention and stimulus-reinforcer interactions in the pigeon. The Quarterly Journal of Experimental Psychology, 38B, 97–110.

    Google Scholar 

  • Kelley, M.J., & Lightman, S. L. (1986). The conditioned release of oxytocin in female rats. Manuscript submitted for publication.

    Google Scholar 

  • Kelley, M. J:, Lightman, S. L., Murphy, D., & O’Connor, K. (1986). Personality, sustained attention and individual differences in nicotine-induced levels of vasopressin. Manuscript submitted for publication.

    Google Scholar 

  • Kennett, D. J., Devlin, M. C., & Ferrier, B. M. (1982). Influence of oxytocin on memory processes: validation by a control study. Life Sciences, 31, 273–275.

    Article  PubMed  Google Scholar 

  • Koob, G. F., LeMoal, M., & Bloom, F. E. (1984). The role of endorphins in neurobiology, behavior, and psychiatric disorders. In C. B. Nemeroff & A.J. Dunn (Eds.), Peptides, hormones and behavior. New York: Spectrum.

    Google Scholar 

  • Koob, G. F., Dantzer, R., Rodriguez, F., Bloom, F. E., & Le Moal, M. (1985). Osmotic stress mimics effects of vasopressin on learned behavior. Nature, 315, 750–752.

    Article  PubMed  Google Scholar 

  • Koob, G. F., LeBrun, C., Martinez, Jr., J. L., Bluthe, R. M., Dantzer, R., Bloom, F. E., & Le Moal, M. (1985). Use of arginine vasopressin antagonists in eliciting the mechanism of action for the behavioral effects of arginine vasopressin. In R. W. Schrier (Eds.), Vasopressin (pp. 195–201). New York: Raven Press.

    Google Scholar 

  • Kovacs, G. L., & Telegdy, G. (1985). Role of oxytocin in memory, amnesia and reinforcement. In J. A. Amico & A. G. Robinson (Eds.), Oxytocin, clinical and laboratory studies (pp. 359–371). New York: Exerpta Medica.

    Google Scholar 

  • Krejci, I., Kupkova, B., Dlaba C.A., & Kasafirek, E. (1983). On the effects of neurohypophyseal hormones, analogs and fragments on the extinction of avoidance responding. In E. Endroczi, L. Angelucci, U. Scapagnini, & de Wied, D. (Eds.), International conference on integrative neurohormonal mechanisms: Neuropeptides and psychosomatic processes. Budapest: Akademiae Kiado.

    Google Scholar 

  • Krieger, D. T. (1983). Brain peptides: What, where, and why? Science, 222, 975–985.

    Article  PubMed  Google Scholar 

  • Laczi, F., Gaffori, O., de Kloet, E. R., & de Wied, D. (1983a). Differential responses in immunoreactive arginine-vasopressin content of microdissected brain regions during passive avoidance behavior. Brain Research, 260, 342–346.

    Article  PubMed  Google Scholar 

  • Laczi, F., Gaffori, O., de Kloet, E. R., & de Wied, D. (1983b). Arginine-vasopressin content of hippocampus and amygdala during passive avoidance behavior in rats. Brain Research, 280, 309–315.

    Article  PubMed  Google Scholar 

  • Laczi, F., Gaffori, O., Fekete, M., de Kloet, E. R., & de Wied, D. (1984). Levels of arginine-vasopressin in cerebrospinal fluid during passive avoidance behavior in rats. Life Sciences, 34, 2385–2391.

    Article  PubMed  Google Scholar 

  • Lader, M. (1980). Psychophysiology studies in anxiety. In G. D. Burrows & B. Davies (Eds.), Handbook of studies on anxiety (pp. 59–88). North Holland: Elsevier.

    Google Scholar 

  • LaHoste, G. J., Olson, G. A., Kaskin, A. J., & Olson, R. D. (1980). Behavioral effects of melanocyte stimulating hormone. Neuroscience and Biobehavioral Reviews, 4, 9–16.

    Article  PubMed  Google Scholar 

  • Lester, L. S., & Fanslow, M. S. (1985). Exposure to a cat produces opioid analgesia in rats. Behavioral Neuroscience, 99, 756–759.

    Article  PubMed  Google Scholar 

  • Mackintosh, N.J. (1983). Conditioning and associative learning. Oxford: Clarendon Press.

    Google Scholar 

  • Macleod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95, 15–20.

    Article  PubMed  Google Scholar 

  • Markey, K. A., & Sze, P. Y. (1984). Influence of ACTH in the locus coeruleus of the mouse brain. Neuroendocrinology, 38, 269–275.

    Article  PubMed  Google Scholar 

  • McGaugh, J. L. (1983). Hormonal influence on memory. Annual Review of Psychology, 34, 297–323.

    Article  PubMed  Google Scholar 

  • Mens, W. B. J., Bouman, H. J., Bakker, E. A. D., & van Wimersma Greidanus, T. B. (1980). Differential effects of various stimuli on AVP levels in blood and cerebrospinal fluid. European Journal of Pharmacology, 68, 89–92.

    Article  PubMed  Google Scholar 

  • Meyer, M. E., & Bohus, B. (1983). The modulation of the dorsal immobility response in the adult Wister rat: The opposite effect of ACTH4–10 and [D-Phe7]ACTH4–10. Behavior and Neural Biology, 38, 194–204.

    Article  Google Scholar 

  • Miller, L. H., Fisher, S. C., Groves, G. A., Rudrauff, M. E., & Kaskin, A. (1977). MSH/ACTH influences on the CAR in human subjects: A negative finding. Pharmacology Biochemistry and Behavior, 7, 417 – 419.

    Article  Google Scholar 

  • Morley, S. (1977). The incubation of avoidance behavior: strain differences in susceptibility. Behavior Research and Therapy, 15, 365–367.

    Article  Google Scholar 

  • Nesse, R. H., Curtis, G. C., Thyer, B. A., McCann, D. S., Huber-Smith, M. J., & Knoff, R. F. (1985). Endocrine and cardiovascular responses during phobic anxiety. Psychosomatic Medicine, 47, 320–332.

    PubMed  Google Scholar 

  • O’Brien, C. P., Ehrman, R. N., & Ternes, J. W. (1986). Classical conditioning in human opioid tolerance. In S. R. Goldberg & I. P. Stolerman (Eds.), Behavioral analysis of drug dependence (pp. 329–356). New York: Academic Press.

    Google Scholar 

  • O’Donohue, T. L., Handelmann, G. E., Miller, R. L., & Jacobowitz, D. M. (1982). N-acetylation regulates the behavioral activity of alpha-melanotropin in a multineurotransmitter neuron. Science, 215, 1125–1127.

    Article  Google Scholar 

  • Nicolaides, E. D., Tinney, F. J., Kaltenbronn, J. S., Repine, D. A., DeJohn, D. A., Lunney, E. A., Roark, W. H., Marriott, J. G., Davis, R. E., & Voigtman, R. E. (1986). Modified di- and tripepetides of the c-terminal portion of oxytocin and vasopressin as possible cognition activation agents. Journal of Medicinal Chemistry, 29, 959–971.

    Article  PubMed  Google Scholar 

  • Æhman, A., Dimberg, U., & Ost, L. (1985). Animal and social phobias: Biological constraints on learned fear responses. In S. Reiss & R. R. Bootzin (Eds.), Theoretical issues in behavior therapy (pp. 123–175). New York: Academic Press.

    Google Scholar 

  • Ælson, G. A., Olson, R. D., & Kaskin, A.J. (1985). Endogenous opiates: 1984. Peptides, 6, 769–791.

    Article  Google Scholar 

  • Pi-Sunyer, X., Kissileff, H. R., Thornton, J., & Smith, G. P. (1982). C-terminal octapeptide of chole- cystokinin decreases food intake in obese men. Physiology and Behavior, 29, 627–630.

    Article  PubMed  Google Scholar 

  • Pigache, R. M., & Righter, H. (1981). The effects of peptides related to ACTH on mood and vigilancein man. In Tj. B. van Wimersma Griedanus & L. H. Rees (Eds.), ACTH and LPH in health and disease (pp. 191–207). Basel: S. Karger.

    Google Scholar 

  • Post, R. M., Pickar, D., Ballenger, J. C., Naber, D., & Rubinow, D. R. (1984). Endogenous opiates in cerebrospinal fluid: Relationship to mood and anxiety. In R. M. Post & J. C. Ballenger (Eds.), Neurobiology of mood disorders (pp. 356–368). London: Williams & Wilkens.

    Google Scholar 

  • Raid-Fahmy, D., Read, G. F., Walker, R. F., & Griffiths, K. (1987). Steroids in saliva for assessing endocrine function. Endocrine Reviews, 3, 367–396.

    Article  Google Scholar 

  • Raskin, M. A., Weitzman, R. E., Orenstein, H., Fisher, D. A., & Courtney, N. (1978). Is antidiuretic hormone elevated in psychosis? A pilot study. Biological Psychiatry, 13, 385–391.

    Google Scholar 

  • Redmond, D. E., Jr. (1981). Clonidine and the primate locus coeruleus: Evidence suggesting anxiolytic and anti-withdrawal effects. In H. Lai & S. Fielding (Eds.), Psychopharmacology of Clonidine. New York: Alan Liss.

    Google Scholar 

  • Redmond, D.E. Jr., & Huang, Y. H. (1979). New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sciences, 25, 2149–2162.

    Article  PubMed  Google Scholar 

  • Riccio, D. C., & Concannon, J. T. (1981). ACTH and the reminder phenomena. In J. L. Martinez, Jr., R. A.Jensen, & R. B. Messing (Eds.), Endogenous peptides and learning and memory processes. New York: Academic Press.

    Google Scholar 

  • Righter, H. (1982). Vasopressin and memory: The influence of prior experience with the training situation. Behavioral Neurobiology, 34, 337–351.

    Google Scholar 

  • Ritzman, R. F., Colbern, D. L., Zimmerman, E. G., & Krivoy, W. (1984). Neurohypophyseal hormones in tolerance and physical dependence. Pharmacology and Therapy, 23, 281–312.

    Article  Google Scholar 

  • Robbins, T. W., Everitt, B. J., & Cole, B. J. (1985). Functional hypotheses of the coeruleocortical noradrenergic projection: A review of recent experimentation and theory. Physiological Psychology, 13, 127–150.

    Google Scholar 

  • Roy-Byrne, P. P., Uhde, T. W., Post, R. M., Gallucci, W., Chrousos, G. P., & Gold, P. W. (1986). The corticotropin-releasing hormone stimulation test in patients with panic disorders. American Journal of Psychiatry, 143, 896–899.

    PubMed  Google Scholar 

  • Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984). Stress down-regulates corticocosterone receptors in a site-specific manner in the brain. Endocrinology, 114, 287–292.

    Article  PubMed  Google Scholar 

  • Sartory, G. (1983). The orienting response and psychopathology: Anxiety and phobias. In D. Siddle (Ed.), Orienting and habituation: Perspectives in human research (pp. 449–474). New York: Wiley.

    Google Scholar 

  • Schacter, S., & Singer, J. (1962). Cognitive social and physiological determinants of emotional state. Psychological Review, 69, 379–399.

    Article  Google Scholar 

  • Shillabeer, G., & Davison, J. S. (1984). The Cholecystokinin antagonist, proglumide, increases food intake in the rat. Regulatory Peptides, 8, 171–176.

    Article  PubMed  Google Scholar 

  • Smock, T., & Fields, H. L. (1981). AGTH 1–24 blocks opiate-induced analgesia in the rat. Brain Research, 212, 202–206.

    Article  PubMed  Google Scholar 

  • Strupp, B. J., & Levitsky, D. A. (1985). A mnemonic role for vasopressin: The evidence for and against. Neuroscience and Biobehavioral Reviews, 9, 399–411.

    Article  PubMed  Google Scholar 

  • Strupp, B. J., & Weingartner, H. (1984). Vasopressin and cognition. Drug Development Research, 4, 501 – 516.

    Article  Google Scholar 

  • Strupp, B., Weingartner, H., Goodwin, F. K., & Gold, P. W. (1984). Neurohypophseal hormones and cognition. Pharmacology and Therapeutics, 23, 179–191.

    Google Scholar 

  • Terman, G. W., Shavit, Y., Lewis, J. W., Cannon, J. T., & Liebeskind, J. C. (1984). Intrinsic mechanisms of pain inhibition: Activation by stress. Science, 226, 1270–1277.

    Article  PubMed  Google Scholar 

  • Timsit-Berthier, M., Mantanus, H., Devos, J. E., & Spiegel, R. (1982). Action of lysine-vasopressin on human electroencephalographic activity. Neuropsychobiology, 8, 248–258.

    Article  PubMed  Google Scholar 

  • Tinus, T. P., Beckwith, B. E., Wagner, N., Tinus, K. A., and Traynor, M. M. (1986). Differential actions of arginine vasopressin and alpha-melanocyte-stimulating hormone on reactivation of memory after hypotherma-induced amnesia. Physiological Psychology, 15–22.

    Google Scholar 

  • Tomkins, E. H., Sturgis, C. C., & Wearn, J. T. (1919). Studies in epinephrine. II. Archives of Internal Medicine, 24, 247–268.

    Article  Google Scholar 

  • Vale, W., & Greer, M. (Eds.). (1985). Proceedings of conference on corticotropin-releasing factor. Federation Proceedings, 44, 145–263.

    Google Scholar 

  • Valentino, R. J., Foote, S. L., & Aston-Jones, G. (1983). CRF activates noradrenergic neurons of the locus coeruleus. Brain Research, 363–369.

    Google Scholar 

  • Vanderhaeghen, J.-J., & Crawley, J. N. (Eds.). (1985). Neuronal cholecystokinin: Annuals of the New York Academy of Sciences, Vol. 448. New York: The New York Academy of Sciences,

    Google Scholar 

  • van der Velde, C. D. (1983). Rapid clinical effectiveness of MIF-1 in the treatment of major depressive illness. Peptides, 4, 297–300.

    Article  PubMed  Google Scholar 

  • van Heuven-Nolsen, D., De Kloet, E. R., & Versteeg, D. H. G. (1984). Oxytocin affects utilization of noradrenaline in distinct limbic-forebrain regions of the rat brain. Neuropharmacology, 23, 1373–1377.

    Article  PubMed  Google Scholar 

  • Van Wimersma Greidanus, Tj B., Bohus, B., Kovacs, G. L., Versteeg, D. H. G., Burbach, J. P. H., & de Wied, D. (1983). Sites of behavioral and neurochemical action of ACTH-like peptides and neurohypophyseal hormones. Neuroscience and Biobehavioral Reviews, 7, 453–463.

    Article  Google Scholar 

  • Veith, J. L., Sandman, C. A., George, J. M., & Kendall, J. W. (1985). The relationship of endogenous ACTH levels to visual-attentional functioning in patients with congenital adrenal hyperplasia. Psychoneuroendocrinology, 10, 33–48.

    Article  PubMed  Google Scholar 

  • Veldhuis, H. D., & de Wied, D. (1984). Differential behavioral actions of corticotropin-releasing factor. Pharmacology Biochemistry and Behavior, 21, 707–714.

    Article  Google Scholar 

  • Verbalis, J. G., McCann, M. J., McHale, C. M., & Strieker, E. M. (1986). Oxytocin secretion in response to cholecystocinin and food: Differentiation of nausea from satiety. Science, 232, 1417–1419.

    Article  PubMed  Google Scholar 

  • von Kronning, L., Almay, B. G. L., Johansson, F., & Terenius, L. (1978). Pain perception and endorphin levels in cerebrospinal fluid. Pain, 5, 359.

    Article  Google Scholar 

  • Watkins, L. R., Kinscheck, I. B., & Mayer, D.J. (1984). Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science, 224, 395–396.

    Article  PubMed  Google Scholar 

  • Watts, F. N., & Sharrock, R. (1985). Description and measurement of concentration problems in depressed patients. Psychological Medicine, 15, 317–326.

    Article  PubMed  Google Scholar 

  • Williams, J. L., Drugan, R. C., & Maier, S. P. (1984). Exposure to uncontrollable stress alters withdrawal from morphine. Behavioral Neuroscience, 98, 836–846.

    Article  PubMed  Google Scholar 

  • Williams, T. D., Carter, D. A., & Lightman, S. L. (1985). Sexual dimorphism in the posterior pituitary response to stress in the rat. Endocrinology, 116, 738–741.

    Article  PubMed  Google Scholar 

  • Wolkowitz, O. M., Tinklenberg, J. R., & Weingartner, H. (1985). A pharmacological perspective of cognitive functions. Neuropsychobiology, 14, 133–156.

    Article  PubMed  Google Scholar 

  • Wood, S. P., Tickle, I. J., Treharne, A. M., Pitts, J. E., Mascarenhas, Y., Li, J. Y., Husain, J., Cooper, S., Bludell, T. L., Hruby, V.J., Buku, A., Fischman, A.J., & Wyssbrod, H. R. (1986). Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding. Science, 232, 633–636.

    Article  PubMed  Google Scholar 

  • Zerbe, R. L. (1985). Genetic factors in normal and abnormal regulation of vasopressin secretion. In R. W. Schrier (Ed.), Vasopressin (pp. 213–220). New York: Raven Press.

    Google Scholar 

  • Zis, A. P., Haskett, R. F., Albala, A., Carroll, B. J., & Lohr, N. E. (1985). Opioid regulation of hypothalamic-pituitary-adrenal function in depression. Archives of General Psychiatry, 42, 383–386.

    Article  PubMed  Google Scholar 

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Kelley, M.J. (1987). Hormones and Clinical Anxiety An Imbalanced Neuromodulation of Attention. In: Eysenck, H.J., Martin, I. (eds) Theoretical Foundations of Behavior Therapy. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0827-8_19

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